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- W77081966 abstract "The immunologic hallmark of successful infection with the Human Immunodeficiency Virus (HIV) is a progressive decline in CD4 T cell count, which ultimately results in the appearance of infections characteristic of acquired immune deficiency syndrome (AIDS). However, prior to this decline in CD4 + T cell number, impairment of T helper cell (Th) function is observed. Alterations in cytokine production could contribute to HIV disease progression by modulating antigen induced cell death (AICD), which has recently been reported to occur preferentially in Th1 cells. This chapter summarizes the evidence that cytokines influence the progression of HIV disease, as well as protection against HIV infection. Cytokines also appear to have an effect on AICD, a model for HIV immunopathogenesis, and on the production of cell generated anti-HIV factors. It remains to be determined whether cytokine-driven immune-based therapies and cytokine-directed prophylactic immunization against HIV and AIDS can be effectively achieved without creating new problems of immune dysregulation. The immunologic components considered likely to contribute to protection against HIV infection and progression to AIDS is listed in chapter. It remains to be determined whether all of these factors of potential immune protection can be optimized simultaneously." @default.
- W77081966 created "2016-06-24" @default.
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- W77081966 date "1999-01-01" @default.
- W77081966 modified "2023-10-18" @default.
- W77081966 title "The Relationships Between Cytokines, Complement and HIV Infection" @default.
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- W77081966 doi "https://doi.org/10.1016/b978-012200741-5/50010-6" @default.
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