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- W77133543 abstract "Carnitine has received attention in the past as a naturally occurring compound which can transiently improve or preserve cardiac performance during myocardial ischemia [1]. An example of this preservative effect on mechanical function is shown in Figure 1 from experimental observations in extracorporeally perfused pig hearts at conditions of moderate global ischemia and excess fatty acids (FFA) in coronary perfusion fluid [2]. The exact mechanism for this therapeutic influence has never been identified but hypotheses have centered on a sparing effect from a deleterious lipid burden known to occur in ischemic heart muscle which drains essential energy stores and disrupts membrane integrity and enzyme functions via accumulation of amphiphiles [3, 4]. Unfortunately, by definition, the benefits of carnitine (or any other therapy) in ischemic myocardium must be short-lived since any treatment strategy in the absence of expeditious repletion of oxygen delivery cannot be sustained for long. Irreversible cardiac injury with its accompanying mechanical dysfunction must occur in a matter of minutes-to-hours." @default.
- W77133543 created "2016-06-24" @default.
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- W77133543 date "1995-01-01" @default.
- W77133543 modified "2023-09-27" @default.
- W77133543 title "Mechanical recovery with propionyl-L-carnitine" @default.
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- W77133543 doi "https://doi.org/10.1007/978-94-011-0275-9_20" @default.
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