Matches in SemOpenAlex for { <https://semopenalex.org/work/W77174059> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W77174059 endingPage "2551" @default.
- W77174059 startingPage "2549" @default.
- W77174059 abstract "AIM: Patients with advanced stage cardiac adenocarcinoma have a very poor prognosis. Surgery is the first choice of treatment for this kind of patients. Peptide hormone gastrin is a recognized growth factor for gastric cancer, and gastrin receptor antagonist proglumide can block the effects of gastrin. The aim of this study was to investigate the actions of proglumide as an adjuvant treatment to improve the postoperative longterm survival rate of patients with cardiac adenocarcinoma. METHODS: We performed a randomized, controlled study of gastrin receptor antagonist proglumide in 301 patients with cardiac adenocarcinoma after proximal subtotal gastrectomy.The oral dose of 0.4 g proglumide thrice daily preprandially was maintained for more than 5 years in 153 cases (proglumidetreatment group). In the control group, 148 patients underwent operation only. In clinicopathologic features, there was no significant difference between the two groups (P＞0.05). Allpatients were followed up during their lifetime, and the survival rates were analyzed combined with clinicopathologic factors by SPSS 11.5 statistical software.TESULTS: The 1, 3, 5 and 10-year survival rate of the patients was 88.4%, 48.8% , 22.6% and 13.4% , respectively. The1, 3, 5 and 10-year survival rate of the proglumide treatment group was 90.2% , 49.7% , 26.8% and 17.6% compared to 86.5% , 48.0% , 18.2% and 8.9% of the control group. There was a significant difference between the two groups (P = 0.0460). The patients in proglumide treatment group had no obvious side effects after administration of the drug, and no definite hepatic and renal function damage was found. According to single factor log-rank analysis, the long-term survival rate was correlated with the primary tumor position (P = 0.0205), length of the tumor (P = 0.0000), property of the operation (P= 0.0000), histopathologic grading(P = 0.0003), infiltrating degree of the tumor (P = 0.0000),influence of lymph node metastasis (P = 0.0000),clinicopathologic staging (P = 0.0000) and administrati" @default.
- W77174059 created "2016-06-24" @default.
- W77174059 creator A5059507748 @default.
- W77174059 creator A5059599680 @default.
- W77174059 creator A5077763447 @default.
- W77174059 creator A5086416018 @default.
- W77174059 date "2005-01-01" @default.
- W77174059 modified "2023-09-24" @default.
- W77174059 title "Long-term effects of proglumide on resection of cardiac adenocarcinoma" @default.
- W77174059 hasPublicationYear "2005" @default.
- W77174059 type Work @default.
- W77174059 sameAs 77174059 @default.
- W77174059 citedByCount "0" @default.
- W77174059 crossrefType "journal-article" @default.
- W77174059 hasAuthorship W77174059A5059507748 @default.
- W77174059 hasAuthorship W77174059A5059599680 @default.
- W77174059 hasAuthorship W77174059A5077763447 @default.
- W77174059 hasAuthorship W77174059A5086416018 @default.
- W77174059 hasConcept C121608353 @default.
- W77174059 hasConcept C126322002 @default.
- W77174059 hasConcept C126894567 @default.
- W77174059 hasConcept C170493617 @default.
- W77174059 hasConcept C2776079162 @default.
- W77174059 hasConcept C2776885963 @default.
- W77174059 hasConcept C2776986829 @default.
- W77174059 hasConcept C2781182431 @default.
- W77174059 hasConcept C32110497 @default.
- W77174059 hasConcept C49039625 @default.
- W77174059 hasConcept C71924100 @default.
- W77174059 hasConcept C90924648 @default.
- W77174059 hasConceptScore W77174059C121608353 @default.
- W77174059 hasConceptScore W77174059C126322002 @default.
- W77174059 hasConceptScore W77174059C126894567 @default.
- W77174059 hasConceptScore W77174059C170493617 @default.
- W77174059 hasConceptScore W77174059C2776079162 @default.
- W77174059 hasConceptScore W77174059C2776885963 @default.
- W77174059 hasConceptScore W77174059C2776986829 @default.
- W77174059 hasConceptScore W77174059C2781182431 @default.
- W77174059 hasConceptScore W77174059C32110497 @default.
- W77174059 hasConceptScore W77174059C49039625 @default.
- W77174059 hasConceptScore W77174059C71924100 @default.
- W77174059 hasConceptScore W77174059C90924648 @default.
- W77174059 hasIssue "17" @default.
- W77174059 hasLocation W771740591 @default.
- W77174059 hasOpenAccess W77174059 @default.
- W77174059 hasPrimaryLocation W771740591 @default.
- W77174059 hasRelatedWork W2008152636 @default.
- W77174059 hasRelatedWork W2048017679 @default.
- W77174059 hasRelatedWork W2069623507 @default.
- W77174059 hasRelatedWork W2075590483 @default.
- W77174059 hasRelatedWork W2134960972 @default.
- W77174059 hasRelatedWork W2249040323 @default.
- W77174059 hasRelatedWork W2318423143 @default.
- W77174059 hasRelatedWork W2363974105 @default.
- W77174059 hasRelatedWork W2366426016 @default.
- W77174059 hasRelatedWork W2366638451 @default.
- W77174059 hasRelatedWork W2372600991 @default.
- W77174059 hasRelatedWork W2374683075 @default.
- W77174059 hasRelatedWork W2376649478 @default.
- W77174059 hasRelatedWork W2378831808 @default.
- W77174059 hasRelatedWork W2390242697 @default.
- W77174059 hasRelatedWork W2439148731 @default.
- W77174059 hasRelatedWork W3030252833 @default.
- W77174059 hasRelatedWork W3032168617 @default.
- W77174059 hasRelatedWork W1768083418 @default.
- W77174059 hasRelatedWork W223795754 @default.
- W77174059 hasVolume "11" @default.
- W77174059 isParatext "false" @default.
- W77174059 isRetracted "false" @default.
- W77174059 magId "77174059" @default.
- W77174059 workType "article" @default.