FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W77201982> ?p ?o ?g. }

• W77201982 abstract "Major histocompatibility complex (MHC) class I and II molecules can both present cytosolic and nuclear antigens to CD8(+) and CD4(+) T cells, respectively. However, MHC class I displays proteasomal, whereas MHC class II molecules display lysosomal, degradation products. One pathway by which intracellular antigens gain access to lysosomal degradation is macroautophagy. Therefore, MHC class II presentation of antigens that are targeted to autophagosomes can be used to investigate regulation events of the macroautophagy pathway. We fuse antigens to Atg8/LC3 for targeting to autophagosomes, because this ubiquitin-like protein is selectively coupled to autophagosome membranes, and the portion that is coupled to the inner autophagosome membrane is degraded with this membrane in lysosomes. The localization of these fusion antigens in MHC class II loading compartments can be visualized by immunofluorescence and electron microscopy, and used as a measure of autophagic amphisome generation. In addition, MHC class II presentation of autophagosome-targeted antigens can be monitored by CD4(+) T cell recognition and indicates completion of macroautophagy. Together these immunological assays are well suited to investigate autophagic flux and analyze experimental conditions and physiological perturbations for their influence on macroautophagy." @default.
• W77201982 created "2016-06-24" @default.
• W77201982 creator A5084915056 @default.
• W77201982 creator A5088131048 @default.
• W77201982 date "2009-01-01" @default.
• W77201982 modified "2023-09-28" @default.
• W77201982 title "Chapter 24 Monitoring Macroautophagy by Major Histocompatibility Complex Class II Presentation of Targeted Antigens" @default.
• W77201982 cites W1502565270 @default.
• W77201982 cites W1665138641 @default.
• W77201982 cites W1976299453 @default.
• W77201982 cites W1977648435 @default.
• W77201982 cites W1988593172 @default.
• W77201982 cites W1994048581 @default.
• W77201982 cites W1994823455 @default.
• W77201982 cites W1997082378 @default.
• W77201982 cites W2000273475 @default.
• W77201982 cites W2046428284 @default.
• W77201982 cites W2046879630 @default.
• W77201982 cites W2048737737 @default.
• W77201982 cites W2055039738 @default.
• W77201982 cites W2055330678 @default.
• W77201982 cites W2060001883 @default.
• W77201982 cites W2062254683 @default.
• W77201982 cites W2063929734 @default.
• W77201982 cites W2065638217 @default.
• W77201982 cites W2069634988 @default.
• W77201982 cites W2074857405 @default.
• W77201982 cites W2076312256 @default.
• W77201982 cites W2081765214 @default.
• W77201982 cites W2096003818 @default.
• W77201982 cites W2097169892 @default.
• W77201982 cites W2104043925 @default.
• W77201982 cites W2121037457 @default.
• W77201982 cites W2122081259 @default.
• W77201982 cites W2129112743 @default.
• W77201982 cites W2138779042 @default.
• W77201982 cites W2149306102 @default.
• W77201982 cites W2165214298 @default.
• W77201982 cites W2169235746 @default.
• W77201982 cites W2792139654 @default.
• W77201982 cites W4251998394 @default.
• W77201982 doi "https://doi.org/10.1016/s0076-6879(08)03624-0" @default.
• W77201982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19200895" @default.
• W77201982 hasPublicationYear "2009" @default.
• W77201982 type Work @default.
• W77201982 sameAs 77201982 @default.
• W77201982 citedByCount "4" @default.
• W77201982 countsByYear W772019822012 @default.
• W77201982 crossrefType "book-chapter" @default.
• W77201982 hasAuthorship W77201982A5084915056 @default.
• W77201982 hasAuthorship W77201982A5088131048 @default.
• W77201982 hasConcept C108249834 @default.
• W77201982 hasConcept C147483822 @default.
• W77201982 hasConcept C168296220 @default.
• W77201982 hasConcept C170627219 @default.
• W77201982 hasConcept C185592680 @default.
• W77201982 hasConcept C190283241 @default.
• W77201982 hasConcept C203014093 @default.
• W77201982 hasConcept C203522944 @default.
• W77201982 hasConcept C207936829 @default.
• W77201982 hasConcept C22845430 @default.
• W77201982 hasConcept C2776090121 @default.
• W77201982 hasConcept C2778814158 @default.
• W77201982 hasConcept C2778973524 @default.
• W77201982 hasConcept C55493867 @default.
• W77201982 hasConcept C83464605 @default.
• W77201982 hasConcept C86803240 @default.
• W77201982 hasConcept C8891405 @default.
• W77201982 hasConcept C95444343 @default.
• W77201982 hasConceptScore W77201982C108249834 @default.
• W77201982 hasConceptScore W77201982C147483822 @default.
• W77201982 hasConceptScore W77201982C168296220 @default.
• W77201982 hasConceptScore W77201982C170627219 @default.
• W77201982 hasConceptScore W77201982C185592680 @default.
• W77201982 hasConceptScore W77201982C190283241 @default.
• W77201982 hasConceptScore W77201982C203014093 @default.
• W77201982 hasConceptScore W77201982C203522944 @default.
• W77201982 hasConceptScore W77201982C207936829 @default.
• W77201982 hasConceptScore W77201982C22845430 @default.
• W77201982 hasConceptScore W77201982C2776090121 @default.
• W77201982 hasConceptScore W77201982C2778814158 @default.
• W77201982 hasConceptScore W77201982C2778973524 @default.
• W77201982 hasConceptScore W77201982C55493867 @default.
• W77201982 hasConceptScore W77201982C83464605 @default.
• W77201982 hasConceptScore W77201982C86803240 @default.
• W77201982 hasConceptScore W77201982C8891405 @default.
• W77201982 hasConceptScore W77201982C95444343 @default.
• W77201982 hasLocation W772019821 @default.
• W77201982 hasOpenAccess W77201982 @default.
• W77201982 hasPrimaryLocation W772019821 @default.
• W77201982 hasRelatedWork W1544565228 @default.
• W77201982 hasRelatedWork W1893872461 @default.
• W77201982 hasRelatedWork W1977648435 @default.
• W77201982 hasRelatedWork W1999022576 @default.
• W77201982 hasRelatedWork W2007542530 @default.
• W77201982 hasRelatedWork W2041638315 @default.
• W77201982 hasRelatedWork W2074857405 @default.
• W77201982 hasRelatedWork W2087846222 @default.
• W77201982 hasRelatedWork W2097939925 @default.
• W77201982 hasRelatedWork W2104043925 @default.

• next