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- W77211602 abstract "SUMMARY Chlorinated phenols were shown to be inhibitors of mixed function oxidation and glucuronidation reactions. The inhibition of 4-methylumbelliferone and 2-aminophenol glucuronidation was strikingly strong, whereas conjugations of testosterone and bilirubin were less sensitive. The inhibition by chlorophenols was a combined effect of both the phenol group and the chlorine substituents of the molecule. Inhibition of glucuronidation reactions by chlorinated phenols was seen in hepatic and in renal microsomes, and in postmitochrondrial supernatant of small intestinal mucosa. A marked inhibition in the activity of UDPglucuronosyltransferase was demonstrated not only in vitro but also in vivo after a large dose of pentachlorophenol." @default.
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- W77211602 date "1981-01-01" @default.
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- W77211602 title "DRUG METABOLIZING ENZYME ACTIVITIES IN RATS EXPOSED TO CHLORINATED PHENOLS" @default.
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- W77211602 doi "https://doi.org/10.1016/b978-0-08-027350-1.50035-9" @default.
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