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• W772666226 abstract "Many important pathogens such as HIV/AIDS, influenza, malaria, dengue and meningitis generally exist in phenotypically distinct serotypes that compete for hosts. Models used to study these diseases appear as meta-population systems. Herein, we revisit one of the multiple strain models that have been used to investigate the dynamics of infectious diseases with co-circulating serotypes or strains, and provide analytical results underlying the numerical investigations. In particular, we establish the necessary conditions for the local asymptotic stability of the steady states and for the existence of oscillatory behaviors via Hopf bifurcation. In addition, we show that the existence of discrete antigenic forms among pathogens can either fully or partially self-organize, where (i) strains exhibit no strain structures and coexist or (ii) antigenic variants sort into non-overlapping or minimally overlapping clusters that either undergo the principle of competitive exclusion exhibiting discrete strain structures, or co-exist cyclically." @default.
• W772666226 created "2016-06-24" @default.
• W772666226 creator A5047222128 @default.
• W772666226 date "2015-09-01" @default.
• W772666226 modified "2023-09-27" @default.
• W772666226 title "Mathematical analysis of a multiple strain, multi-locus-allele system for antigenically variable infectious diseases revisited" @default.
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• W772666226 doi "https://doi.org/10.1016/j.mbs.2015.06.007" @default.
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