Matches in SemOpenAlex for { <https://semopenalex.org/work/W772914965> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W772914965 abstract "In this thesis, two potential endogenous mechanisms for neuronal survival and repair have been investigated in a rat model of stroke, middle cerebral artery occlusion (MCAO): signaling of the GDNF family of neurotrophic factors, and neurogenesis from endogenous progenitor cells.As determined by in situ hybridization for GDNF family ligand and receptor genes, MCAO caused widespread upregulation of both components of the functional GDNF receptor, c-Ret and GFRalpha1, indicating that GDNF may be a survival signal in stroke. However, viral vector-mediated GDNF gene transfer to the striatum prior to MCAO could not alleviate long-term neuronal loss or functional deficits, and actually exacerbated neuronal loss in one experiment. Neurogenesis was evaluated by labeling proliferating cells with the thymidine analogue BrdU, and confirming neuronal identity with double-label immunohistochemistry. In the dentate gyrus of the hippocampus, where neurogenesis is continuously ongoing, MCAO caused a pronounced but transient NMDA receptor-mediated increase in neurogenesis. In addition, neurogenesis was also seen in the striatum. Newly formed, immature neurons could be seen migrating from an expanded SVZ into the injured area of the striatum. Many newly formed cells subsequently expressed a marker of mature striatal projection neurons.This thesis demonstrates, that the role of GDNF in stroke is more complex than previously believed, and that high levels of this factor can increase ischemic damage. Furthermore, neurogenesis is stimulated by stroke, and a mechanism for neuronal replacement following ischemic damage exists in the brain. If this response can be stimulated, new strategies for treatment of stroke may be developed." @default.
- W772914965 created "2016-06-24" @default.
- W772914965 creator A5005167902 @default.
- W772914965 date "2003-01-01" @default.
- W772914965 modified "2023-09-30" @default.
- W772914965 title "Neuroprotection and neurogenesis after experimental stroke" @default.
- W772914965 hasPublicationYear "2003" @default.
- W772914965 type Work @default.
- W772914965 sameAs 772914965 @default.
- W772914965 citedByCount "0" @default.
- W772914965 crossrefType "dissertation" @default.
- W772914965 hasAuthorship W772914965A5005167902 @default.
- W772914965 hasConcept C126322002 @default.
- W772914965 hasConcept C160539049 @default.
- W772914965 hasConcept C169760540 @default.
- W772914965 hasConcept C170493617 @default.
- W772914965 hasConcept C185856081 @default.
- W772914965 hasConcept C25498285 @default.
- W772914965 hasConcept C2776464000 @default.
- W772914965 hasConcept C2780062018 @default.
- W772914965 hasConcept C2781161787 @default.
- W772914965 hasConcept C4746552 @default.
- W772914965 hasConcept C513476851 @default.
- W772914965 hasConcept C71924100 @default.
- W772914965 hasConcept C86803240 @default.
- W772914965 hasConceptScore W772914965C126322002 @default.
- W772914965 hasConceptScore W772914965C160539049 @default.
- W772914965 hasConceptScore W772914965C169760540 @default.
- W772914965 hasConceptScore W772914965C170493617 @default.
- W772914965 hasConceptScore W772914965C185856081 @default.
- W772914965 hasConceptScore W772914965C25498285 @default.
- W772914965 hasConceptScore W772914965C2776464000 @default.
- W772914965 hasConceptScore W772914965C2780062018 @default.
- W772914965 hasConceptScore W772914965C2781161787 @default.
- W772914965 hasConceptScore W772914965C4746552 @default.
- W772914965 hasConceptScore W772914965C513476851 @default.
- W772914965 hasConceptScore W772914965C71924100 @default.
- W772914965 hasConceptScore W772914965C86803240 @default.
- W772914965 hasLocation W7729149651 @default.
- W772914965 hasOpenAccess W772914965 @default.
- W772914965 hasPrimaryLocation W7729149651 @default.
- W772914965 hasRelatedWork W1604323431 @default.
- W772914965 hasRelatedWork W1985899045 @default.
- W772914965 hasRelatedWork W2008693971 @default.
- W772914965 hasRelatedWork W2028832381 @default.
- W772914965 hasRelatedWork W2054119137 @default.
- W772914965 hasRelatedWork W2073325922 @default.
- W772914965 hasRelatedWork W2079919093 @default.
- W772914965 hasRelatedWork W2081810965 @default.
- W772914965 hasRelatedWork W2088746866 @default.
- W772914965 hasRelatedWork W2332919624 @default.
- W772914965 hasRelatedWork W2513727606 @default.
- W772914965 hasRelatedWork W2554656236 @default.
- W772914965 hasRelatedWork W2557120632 @default.
- W772914965 hasRelatedWork W2805626897 @default.
- W772914965 hasRelatedWork W2901978068 @default.
- W772914965 hasRelatedWork W2996963173 @default.
- W772914965 hasRelatedWork W62519176 @default.
- W772914965 hasRelatedWork W771905159 @default.
- W772914965 hasRelatedWork W2614007275 @default.
- W772914965 hasRelatedWork W3143256114 @default.
- W772914965 isParatext "false" @default.
- W772914965 isRetracted "false" @default.
- W772914965 magId "772914965" @default.
- W772914965 workType "dissertation" @default.