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- W77304888 abstract "ANG II generated in blood has a wide spectrum of biological actions on a variety of tissues. Included are effects on smooth and cardiac muscles, modification of other hormone release, and brain actions such as drinking behaviour, neurogenic hypertension and sodium appetite. All are fast-acting with short durations, suggesting that ANG II is a hormone that responds to emergent changes in the internal or external environment and initiates physiological reactions to restore the status quo ante. In the case of hemorrhage, for example, renin is secreted immediately in response to hypovolemia/hypotension and sympathetic activationj the resulting elevation of plasma ANG II induces drinking and sodium appetite, and increases intestinal absorption of water and Na+ to restore their loss. ANG II acts also on the kidney to decrease the urinary loss of water and Na+. Furthermore, ANG II stimulates the secretion of vasopressin and aldosterone to decrease the loss of water and Na+. In this way, blood volume is restored. The circulating RAS seems to be the first humoral messenger responsible for the initiation of an emergency reaction (Kobayashi and Takei 1982; Kobayashi et al. 1983; Sects 8.2.5, 8.3.1, 9.4.3)." @default.
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- W77304888 date "1996-01-01" @default.
- W77304888 modified "2023-10-03" @default.
- W77304888 title "Biological Actions of ANG II" @default.
- W77304888 doi "https://doi.org/10.1007/978-3-642-61164-3_8" @default.
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