Matches in SemOpenAlex for { <https://semopenalex.org/work/W773276768> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W773276768 abstract "Energetic heavy ions pose a health risk to astronauts in extended ISS and future Mars missions. High-LET heavy ions are particularly effective in causing various biological effects including cell inactivation, genetic mutations and cancer induction. Most of these biological endpoints are closely related to chromosomal damage, which can be utilized as a biomarker for radiation insults. Previously, we had studied chromosome aberrations in human lymphocytes and fibroblasts induced by both low- and high-LET radiation using FISH and multicolor fluorescence in situ hybridization (mFISH) techniques. In this study, we exposed human epithelial cells in vitro to gamma rays and energetic particles of varying types and energies and dose rates, and analyzed chromosomal damages using the multicolor banding in situ hybridization (mBAND) procedure. Confluent human epithelial cells (CH184B5F5/M10) were exposed to energetic heavy ions at NASA Space Radiation Laboratory (NSRL) at the Brookhaven National Laboratory, high energy neutron at the Los Alamos Nuclear Science Center (LANSCE) or Cs-137-gamma radiation source at the University of Texas, MD Anderson Cancer Center. After colcemid and Calyculin A treatment, cells were fixed and painted with XCyte3 mBAND kit (MetaSystems) and chromosome aberrations were analyzed with mBAND analysis system (MetaSystems). With this technique, individually painted chromosomal bands on one chromosome allowed the identification of interchromosomal aberrations (translocation to unpainted chromosomes) and intrachromosomal aberrations (inversions and deletions within a single painted chromosome). The results of the mBAND study showed a higher ratio of inversion involved with interchromosomal exchange in heavy ions compared to -ray irradiation. Analysis of chromosome aberrations using mBAND has the potential to provide useful information on human cell response to space-like radiation." @default.
- W773276768 created "2016-06-24" @default.
- W773276768 creator A5003597482 @default.
- W773276768 creator A5017596885 @default.
- W773276768 creator A5024163414 @default.
- W773276768 creator A5036907286 @default.
- W773276768 creator A5045349713 @default.
- W773276768 creator A5059239993 @default.
- W773276768 date "2006-07-23" @default.
- W773276768 modified "2023-09-28" @default.
- W773276768 title "Inter- and Intra-Chromosomal Aberrations in Human Cells Exposed in vitro to High and Low LET Radiations" @default.
- W773276768 hasPublicationYear "2006" @default.
- W773276768 type Work @default.
- W773276768 sameAs 773276768 @default.
- W773276768 citedByCount "0" @default.
- W773276768 crossrefType "journal-article" @default.
- W773276768 hasAuthorship W773276768A5003597482 @default.
- W773276768 hasAuthorship W773276768A5017596885 @default.
- W773276768 hasAuthorship W773276768A5024163414 @default.
- W773276768 hasAuthorship W773276768A5036907286 @default.
- W773276768 hasAuthorship W773276768A5045349713 @default.
- W773276768 hasAuthorship W773276768A5059239993 @default.
- W773276768 hasConcept C104317684 @default.
- W773276768 hasConcept C111337013 @default.
- W773276768 hasConcept C121332964 @default.
- W773276768 hasConcept C153911025 @default.
- W773276768 hasConcept C178108356 @default.
- W773276768 hasConcept C185544564 @default.
- W773276768 hasConcept C2777542201 @default.
- W773276768 hasConcept C2994296024 @default.
- W773276768 hasConcept C30481170 @default.
- W773276768 hasConcept C54355233 @default.
- W773276768 hasConcept C86611320 @default.
- W773276768 hasConcept C86803240 @default.
- W773276768 hasConceptScore W773276768C104317684 @default.
- W773276768 hasConceptScore W773276768C111337013 @default.
- W773276768 hasConceptScore W773276768C121332964 @default.
- W773276768 hasConceptScore W773276768C153911025 @default.
- W773276768 hasConceptScore W773276768C178108356 @default.
- W773276768 hasConceptScore W773276768C185544564 @default.
- W773276768 hasConceptScore W773276768C2777542201 @default.
- W773276768 hasConceptScore W773276768C2994296024 @default.
- W773276768 hasConceptScore W773276768C30481170 @default.
- W773276768 hasConceptScore W773276768C54355233 @default.
- W773276768 hasConceptScore W773276768C86611320 @default.
- W773276768 hasConceptScore W773276768C86803240 @default.
- W773276768 hasLocation W7732767681 @default.
- W773276768 hasOpenAccess W773276768 @default.
- W773276768 hasPrimaryLocation W7732767681 @default.
- W773276768 hasRelatedWork W1543433242 @default.
- W773276768 hasRelatedWork W1637587117 @default.
- W773276768 hasRelatedWork W1965570751 @default.
- W773276768 hasRelatedWork W2021367141 @default.
- W773276768 hasRelatedWork W2094271869 @default.
- W773276768 hasRelatedWork W2117115847 @default.
- W773276768 hasRelatedWork W2117477807 @default.
- W773276768 hasRelatedWork W2142711977 @default.
- W773276768 hasRelatedWork W2163726032 @default.
- W773276768 hasRelatedWork W2171803653 @default.
- W773276768 hasRelatedWork W2193477924 @default.
- W773276768 hasRelatedWork W2292816259 @default.
- W773276768 hasRelatedWork W2413629992 @default.
- W773276768 hasRelatedWork W3155319061 @default.
- W773276768 hasRelatedWork W3182233639 @default.
- W773276768 hasRelatedWork W793227425 @default.
- W773276768 hasRelatedWork W827230818 @default.
- W773276768 hasRelatedWork W840025385 @default.
- W773276768 hasRelatedWork W857890151 @default.
- W773276768 hasRelatedWork W931734827 @default.
- W773276768 isParatext "false" @default.
- W773276768 isRetracted "false" @default.
- W773276768 magId "773276768" @default.
- W773276768 workType "article" @default.