Matches in SemOpenAlex for { <https://semopenalex.org/work/W773919997> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W773919997 abstract "Differentiation from hematopoietic stem cells to mature blood cells of different lineages is a continuous process that requires the coordinated activity of several stage and lineage specific transcription factors. These factors act in a transcriptional hierarchy and also in a combinatorial manner to establish the expression of the genes that comprise a specific differentiation program. The progression of hematopoietic progenitors to the earliest committed B cells is highly dependent of the transcription factor Early B-cell Factor (EBF). In the absence of this factor, B-cell development is arrested at the earliest pre-pro-B-cell stage, while all the other blood cell lineages appear to develop normally. To gain further insight in how B-lineage commitment is achieved we have investigated control elements and factors affecting the expression and functional activity of EBF. The identification and cloning of a promoter region flanking the EBF gene revealed that EBF is controlled by auto-regulation and provided additional support for the existence of a transcription factor hierarchy in early B cell development. We have also examined how signaling through the surface receptor Notch affects EBF activity. It is well established that Notch signaling is involved in early lineage decision events, promoting T- on behalf of B-cell differentiation. One important property of Notch in this course of events seems to be its ability to perturb the functional activity of EBF. Moreover, Notch signaling has the capacity to alter fate of already committed B-cells towards T-lineage, even though this feature is rare and only observed in the earliest pre-pro-B cells. (Less)" @default.
- W773919997 created "2016-06-24" @default.
- W773919997 creator A5063151245 @default.
- W773919997 date "2005-01-01" @default.
- W773919997 modified "2023-09-28" @default.
- W773919997 title "Genetic networks dictating early lymphoid lineage decision events" @default.
- W773919997 hasPublicationYear "2005" @default.
- W773919997 type Work @default.
- W773919997 sameAs 773919997 @default.
- W773919997 citedByCount "0" @default.
- W773919997 crossrefType "dissertation" @default.
- W773919997 hasAuthorship W773919997A5063151245 @default.
- W773919997 hasConcept C104317684 @default.
- W773919997 hasConcept C109159458 @default.
- W773919997 hasConcept C148738053 @default.
- W773919997 hasConcept C159654299 @default.
- W773919997 hasConcept C161879069 @default.
- W773919997 hasConcept C201750760 @default.
- W773919997 hasConcept C203014093 @default.
- W773919997 hasConcept C2776817793 @default.
- W773919997 hasConcept C2778453870 @default.
- W773919997 hasConcept C28328180 @default.
- W773919997 hasConcept C54355233 @default.
- W773919997 hasConcept C62478195 @default.
- W773919997 hasConcept C86339819 @default.
- W773919997 hasConcept C86803240 @default.
- W773919997 hasConcept C95444343 @default.
- W773919997 hasConceptScore W773919997C104317684 @default.
- W773919997 hasConceptScore W773919997C109159458 @default.
- W773919997 hasConceptScore W773919997C148738053 @default.
- W773919997 hasConceptScore W773919997C159654299 @default.
- W773919997 hasConceptScore W773919997C161879069 @default.
- W773919997 hasConceptScore W773919997C201750760 @default.
- W773919997 hasConceptScore W773919997C203014093 @default.
- W773919997 hasConceptScore W773919997C2776817793 @default.
- W773919997 hasConceptScore W773919997C2778453870 @default.
- W773919997 hasConceptScore W773919997C28328180 @default.
- W773919997 hasConceptScore W773919997C54355233 @default.
- W773919997 hasConceptScore W773919997C62478195 @default.
- W773919997 hasConceptScore W773919997C86339819 @default.
- W773919997 hasConceptScore W773919997C86803240 @default.
- W773919997 hasConceptScore W773919997C95444343 @default.
- W773919997 hasLocation W7739199971 @default.
- W773919997 hasOpenAccess W773919997 @default.
- W773919997 hasPrimaryLocation W7739199971 @default.
- W773919997 hasRelatedWork W1509420562 @default.
- W773919997 hasRelatedWork W1521353146 @default.
- W773919997 hasRelatedWork W1980303101 @default.
- W773919997 hasRelatedWork W1987028912 @default.
- W773919997 hasRelatedWork W2010614196 @default.
- W773919997 hasRelatedWork W2019564131 @default.
- W773919997 hasRelatedWork W2020713861 @default.
- W773919997 hasRelatedWork W2024488862 @default.
- W773919997 hasRelatedWork W2035742591 @default.
- W773919997 hasRelatedWork W2042155385 @default.
- W773919997 hasRelatedWork W2059817275 @default.
- W773919997 hasRelatedWork W2078663836 @default.
- W773919997 hasRelatedWork W2143223192 @default.
- W773919997 hasRelatedWork W2153811681 @default.
- W773919997 hasRelatedWork W2166403834 @default.
- W773919997 hasRelatedWork W2334677697 @default.
- W773919997 hasRelatedWork W2365710645 @default.
- W773919997 hasRelatedWork W2394821915 @default.
- W773919997 hasRelatedWork W2401885945 @default.
- W773919997 hasRelatedWork W2464730303 @default.
- W773919997 isParatext "false" @default.
- W773919997 isRetracted "false" @default.
- W773919997 magId "773919997" @default.
- W773919997 workType "dissertation" @default.