FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W77444976> ?p ?o ?g. }

• W77444976 endingPage "10" @default.
• W77444976 startingPage "3" @default.
• W77444976 abstract "Regulation of the contractile apparatus in vertebrate smooth muscle is thought to involve the phosphorylation-dephosphorylation of the two 20,000-dalton light chains of myosin (Hartshorne, 1987). It has been known for many years that contraction in smooth muscle, as in skeletal muscle, is determined by the concentration of intracellular Ca2+. Contractile activity is coupled to the Ca2+ transients via the formation of the Ca2+-calmodulin (CaM) complex and subsequent activation of the CaM-dependent enzyme, myosin light chain kinase (MLCK). Phosphorylation of the myosin light chain increases the actin-activated ATPase activity of myosin and this event is thought to be reflected, under physiological conditions, by an increased rate of cross-bridge cycling and the development of tension. As long as the intracellular Ca2+ concentration remains above the threshold determined by the affinity of Ca2+ binding to the Ca2+-CaM-MLCK complex (i.e. ∼ 0.5 μM) myosin remains phosphorylated and contraction persists. Reduction in the Ca2+ level leads to a commensurate decrease in kinase activity and varying extents of myosin dephosphorylation. It is assumed (in the absence of conflicting data) that the myosin phosphatase is unregulated and dephosphorylation occurs at the same rate both in the presence and absence of Ca2+. However, the identity of the phosphatase involved in myosin dephosphorylation has not been established and one of the intriguing questions to be answered is whether phosphatase activity is regulated in vivo? Thus, by decreasing the MLCK activity the balance of phosphorylation to dephosphorylation is altered. In the simplest scenario the role of myosin phosphorylation is to initiate contraction and dephosphorylation leads to relaxation. While this simple relationship is not obvious under physiological conditions, and several papers in this volume attest to the complexity of the situation, it is clear that two key regulatory enzymes in smooth muscle are MLCK and myosin phosphatase." @default.
• W77444976 created "2016-06-24" @default.
• W77444976 creator A5052936148 @default.
• W77444976 creator A5073290549 @default.
• W77444976 creator A5080940034 @default.
• W77444976 date "1991-01-01" @default.
• W77444976 modified "2023-10-18" @default.
• W77444976 title "Structure-Function Relationships in Smooth Muscle Myosin Light Chain Kinase" @default.
• W77444976 cites W1503344811 @default.
• W77444976 cites W1504338510 @default.
• W77444976 cites W1530511105 @default.
• W77444976 cites W1542122911 @default.
• W77444976 cites W1546431662 @default.
• W77444976 cites W1585374470 @default.
• W77444976 cites W1601913333 @default.
• W77444976 cites W1670623565 @default.
• W77444976 cites W1873199501 @default.
• W77444976 cites W2017784139 @default.
• W77444976 cites W2035745275 @default.
• W77444976 cites W2043563082 @default.
• W77444976 cites W2090461679 @default.
• W77444976 cites W2091320319 @default.
• W77444976 cites W2091673674 @default.
• W77444976 cites W2092236849 @default.
• W77444976 cites W2094189309 @default.
• W77444976 cites W2097055994 @default.
• W77444976 cites W2161292994 @default.
• W77444976 cites W222506362 @default.
• W77444976 cites W314850954 @default.
• W77444976 doi "https://doi.org/10.1007/978-1-4684-6003-2_2" @default.
• W77444976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1803904" @default.
• W77444976 hasPublicationYear "1991" @default.
• W77444976 type Work @default.
• W77444976 sameAs 77444976 @default.
• W77444976 citedByCount "3" @default.
• W77444976 countsByYear W774449762012 @default.
• W77444976 crossrefType "book-chapter" @default.
• W77444976 hasAuthorship W77444976A5052936148 @default.
• W77444976 hasAuthorship W77444976A5073290549 @default.
• W77444976 hasAuthorship W77444976A5080940034 @default.
• W77444976 hasConcept C11960822 @default.
• W77444976 hasConcept C12554922 @default.
• W77444976 hasConcept C15954220 @default.
• W77444976 hasConcept C178666793 @default.
• W77444976 hasConcept C181199279 @default.
• W77444976 hasConcept C181912034 @default.
• W77444976 hasConcept C184235292 @default.
• W77444976 hasConcept C185592680 @default.
• W77444976 hasConcept C18923293 @default.
• W77444976 hasConcept C2779938346 @default.
• W77444976 hasConcept C29688787 @default.
• W77444976 hasConcept C55493867 @default.
• W77444976 hasConcept C6997183 @default.
• W77444976 hasConcept C79879829 @default.
• W77444976 hasConcept C8035138 @default.
• W77444976 hasConcept C86803240 @default.
• W77444976 hasConcept C95444343 @default.
• W77444976 hasConceptScore W77444976C11960822 @default.
• W77444976 hasConceptScore W77444976C12554922 @default.
• W77444976 hasConceptScore W77444976C15954220 @default.
• W77444976 hasConceptScore W77444976C178666793 @default.
• W77444976 hasConceptScore W77444976C181199279 @default.
• W77444976 hasConceptScore W77444976C181912034 @default.
• W77444976 hasConceptScore W77444976C184235292 @default.
• W77444976 hasConceptScore W77444976C185592680 @default.
• W77444976 hasConceptScore W77444976C18923293 @default.
• W77444976 hasConceptScore W77444976C2779938346 @default.
• W77444976 hasConceptScore W77444976C29688787 @default.
• W77444976 hasConceptScore W77444976C55493867 @default.
• W77444976 hasConceptScore W77444976C6997183 @default.
• W77444976 hasConceptScore W77444976C79879829 @default.
• W77444976 hasConceptScore W77444976C8035138 @default.
• W77444976 hasConceptScore W77444976C86803240 @default.
• W77444976 hasConceptScore W77444976C95444343 @default.
• W77444976 hasLocation W774449761 @default.
• W77444976 hasLocation W774449762 @default.
• W77444976 hasOpenAccess W77444976 @default.
• W77444976 hasPrimaryLocation W774449761 @default.
• W77444976 hasRelatedWork W1488840872 @default.
• W77444976 hasRelatedWork W1589149116 @default.
• W77444976 hasRelatedWork W1999888222 @default.
• W77444976 hasRelatedWork W2022515426 @default.
• W77444976 hasRelatedWork W2022915605 @default.
• W77444976 hasRelatedWork W2068670307 @default.
• W77444976 hasRelatedWork W2169666426 @default.
• W77444976 hasRelatedWork W2394775602 @default.
• W77444976 hasRelatedWork W77444976 @default.
• W77444976 hasRelatedWork W2013423449 @default.
• W77444976 isParatext "false" @default.
• W77444976 isRetracted "false" @default.
• W77444976 magId "77444976" @default.
• W77444976 workType "book-chapter" @default.