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- W77534145 abstract "AbstractThe constant threat by a countless array of environmental poisons, natural products and synthetic agents, over evolutionary time has led living organisms to develop many elaborate mechanisms that combat the toxic effects of these insults. Among such mechanisms is one that decreases the intracellular accumulation of a toxic substance by directly pumping toxic molecules out of the cells, and another that modifies the metabolism of the toxic substances and effluxes the metabolized compounds. The former mechanism is typified by the mammalian multidrug resistance system mediated by P-glycoproteins (P-gp) that are encoded by the MDR gene family. The second mechanism is exemplified by the multidrug resistance protein (MRP). Both P-gp and MRP contain ATP-binding cassettes and therefore belong to the ABC superfamily of membrane transportersKeywordsMultiple MyelomaAcute Myeloid LeukemiaMultidrug ResistanceAcute Myeloblastic LeukemiaMulti Drug Resistance ProteinThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W77534145 created "2016-06-24" @default.
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- W77534145 date "2002-01-01" @default.
- W77534145 modified "2023-09-24" @default.
- W77534145 title "MDR and MRP Gene Families as Cellular Determinant Factors for Resistance to Clinical Anticancer Agents" @default.
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- W77534145 doi "https://doi.org/10.1007/978-1-4615-1173-1_3" @default.
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