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- W7756613 abstract "Aspirin has been shown to acutely block the natriuretic effect of spironolactone in the mineralocorticoid-treated normal rat, dog, and man. It has been suggested that aspirin is contraindicated in hypertensive patients receiving spironolactone. Five patients with low-renin essential hypertension and two with hypertension due to primary aldosteronism, all of whom have normalized their blood pressure on chronic spironolactone therapy, were cotreated in a double-blind fashion with either aspirin or aspirin-placebo during alternate six-week periods. Aspirin did not appear to alter the effect of spironolactone on blood pressure, serum electrolytes, urea nitrogen, or plasma renin activity." @default.
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- W7756613 date "1976-08-01" @default.
- W7756613 modified "2023-10-18" @default.
- W7756613 title "Failure of Aspirin to Antagonize the Antihypertensive Effect of Spironolactone in Low-Renin Hypertension" @default.
- W7756613 doi "https://doi.org/10.1097/00007611-197608000-00022" @default.
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