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- W775695767 abstract "Objectives Two strains of Pseudomonas aeruginosa, B and J-2, have been isolated from sputa of Swedish cystic fibrosis patients and were identified as the most frequent genotypes. Their pathogenic potential differs distinctly: while strain J-2 is highly transmissible and multi-resistant, strain B is not. The aim of the present work is to investigate the proteome to reveal differences between these two strains. Methods We employed a comparative proteomic approach involving twodimensional gel electrophoresis coupled to matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry with isobaric tags for relative and absolute quantitation (iTRAQ) to map the proteomes of B and J-2 and to identify differentially expressed proteins. Results We identified 1873 proteins and quantified 1769 proteins of which about 21% were differentially expressed at statistically significant altered abundance between the two analysed strains. Functional analysis of the different abundant proteins showed they could be clustered into five major groups i.secreted factors; ii.cell wall/LPS/capsule; iii.chemotaxis; iv.motility & attachment; v.adaption/protection. Within the functional clusters, upregulated proteins (q Conclusion This work provides the first overview of P. aeruginosa strains J-2 and B on proteome changes occurring during adaptation to the CF lung and/or antibiotic treatments. The identified altered virulence profile of strain J-2 might contribute to its pathogenicity and transmission ability." @default.
- W775695767 created "2016-06-24" @default.
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- W775695767 date "2015-06-01" @default.
- W775695767 modified "2023-10-07" @default.
- W775695767 title "WS19.8 Comparative proteomic profiling of two Swedish CF Pseudomonas aeruginosa isolates reveals possible factors associated with the transmissible cystic fibrosis strain J-2" @default.
- W775695767 doi "https://doi.org/10.1016/s1569-1993(15)30115-6" @default.
- W775695767 hasPublicationYear "2015" @default.
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