Matches in SemOpenAlex for { <https://semopenalex.org/work/W77586585> ?p ?o ?g. }
- W77586585 endingPage "170" @default.
- W77586585 startingPage "153" @default.
- W77586585 abstract "Numerous human diseases are caused by excessive signaling of mutant G protein-coupled receptors (GPCRs) or receptors that are overstimulated due to upstream signaling imbalances. The feasibility of functional compensation by arrestins with enhanced ability to quench receptor signaling was recently tested in the visual system. The results showed that even in this extremely demanding situation of rods that have no ability to phosphorylate rhodopsin, enhanced arrestin improved rod morphology, light sensitivity, survival, and accelerated photoresponse recovery. Structurally distinct enhanced mutants of arrestins that bind phosphorylated and non-phosphorylated active GPCRs with much higher affinity than parental wild-type (WT) proteins have been constructed. These super-arrestins are likely to have the power to dampen the signaling by hyperactive GPCRs. However, most cells express 5-20 GPCR subtypes, only one of which would be overactive, while nonvisual arrestins are remarkably promiscuous, binding hundreds of different GPCRs. Thus, to be therapeutically useful, enhanced versions of nonvisual arrestins must be made fairly specific for particular receptors. Recent identification of very few arrestin residues as key receptor discriminators paves the way to the construction of receptor subtype-specific nonvisual arrestins." @default.
- W77586585 created "2016-06-24" @default.
- W77586585 creator A5034517130 @default.
- W77586585 creator A5038152713 @default.
- W77586585 creator A5044103642 @default.
- W77586585 date "2013-11-05" @default.
- W77586585 modified "2023-10-16" @default.
- W77586585 title "Targeting Individual GPCRs with Redesigned Nonvisual Arrestins" @default.
- W77586585 cites W1486226554 @default.
- W77586585 cites W1498831674 @default.
- W77586585 cites W1501713341 @default.
- W77586585 cites W1521219614 @default.
- W77586585 cites W1562093773 @default.
- W77586585 cites W1603105681 @default.
- W77586585 cites W1670640460 @default.
- W77586585 cites W1909076506 @default.
- W77586585 cites W1947058321 @default.
- W77586585 cites W1955508706 @default.
- W77586585 cites W1964375924 @default.
- W77586585 cites W1966560373 @default.
- W77586585 cites W1967954611 @default.
- W77586585 cites W1968889576 @default.
- W77586585 cites W1969041583 @default.
- W77586585 cites W1974710770 @default.
- W77586585 cites W1978167732 @default.
- W77586585 cites W1981561980 @default.
- W77586585 cites W1982690891 @default.
- W77586585 cites W1983574848 @default.
- W77586585 cites W1983647208 @default.
- W77586585 cites W1985068778 @default.
- W77586585 cites W1985884328 @default.
- W77586585 cites W1990240164 @default.
- W77586585 cites W1990588211 @default.
- W77586585 cites W1994539207 @default.
- W77586585 cites W1995182632 @default.
- W77586585 cites W2000829099 @default.
- W77586585 cites W2006803138 @default.
- W77586585 cites W2007182763 @default.
- W77586585 cites W2009742151 @default.
- W77586585 cites W2011612766 @default.
- W77586585 cites W2012665233 @default.
- W77586585 cites W2013468241 @default.
- W77586585 cites W2015139671 @default.
- W77586585 cites W2017167286 @default.
- W77586585 cites W2017218397 @default.
- W77586585 cites W2017875329 @default.
- W77586585 cites W2018506708 @default.
- W77586585 cites W2021607480 @default.
- W77586585 cites W2023661096 @default.
- W77586585 cites W2025472785 @default.
- W77586585 cites W2025605951 @default.
- W77586585 cites W2025692747 @default.
- W77586585 cites W2027030905 @default.
- W77586585 cites W2028645925 @default.
- W77586585 cites W2033688302 @default.
- W77586585 cites W2034110062 @default.
- W77586585 cites W2037714888 @default.
- W77586585 cites W2038863418 @default.
- W77586585 cites W2040130844 @default.
- W77586585 cites W2041147285 @default.
- W77586585 cites W2041654178 @default.
- W77586585 cites W2042132016 @default.
- W77586585 cites W2044092807 @default.
- W77586585 cites W2045106976 @default.
- W77586585 cites W2045794140 @default.
- W77586585 cites W2046562640 @default.
- W77586585 cites W2048310909 @default.
- W77586585 cites W2054663006 @default.
- W77586585 cites W2056599855 @default.
- W77586585 cites W2057006179 @default.
- W77586585 cites W2059220343 @default.
- W77586585 cites W2060207881 @default.
- W77586585 cites W2061109953 @default.
- W77586585 cites W2062048451 @default.
- W77586585 cites W2062207135 @default.
- W77586585 cites W2065417808 @default.
- W77586585 cites W2067482553 @default.
- W77586585 cites W2068003883 @default.
- W77586585 cites W2069805230 @default.
- W77586585 cites W2072470496 @default.
- W77586585 cites W2075668934 @default.
- W77586585 cites W2077936290 @default.
- W77586585 cites W2079311820 @default.
- W77586585 cites W2079520721 @default.
- W77586585 cites W2080683650 @default.
- W77586585 cites W2083641353 @default.
- W77586585 cites W2084888272 @default.
- W77586585 cites W2087085101 @default.
- W77586585 cites W2087163465 @default.
- W77586585 cites W2090858556 @default.
- W77586585 cites W2092532048 @default.
- W77586585 cites W2095110617 @default.
- W77586585 cites W2099633074 @default.
- W77586585 cites W2102998045 @default.
- W77586585 cites W2107548301 @default.
- W77586585 cites W2111373319 @default.
- W77586585 cites W2114487805 @default.
- W77586585 cites W2116949924 @default.