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- W77605619 abstract "This chapter discusses OK432 that augments natural killer (NK) activity in vitro independently of interferon (IFN) induction, even in the presence of NK suppressor cells. In a study described in the chapter, blood lymphocytes were incubated alone or with 50 μg OK432 per ml for 20 h at 37°C, then washed and tested for NK activity against K562 cells in a 4-hour chromium release assay. The mechanism by which OK432 augments NK activity was examined. Soluble factors produced by lymphocyte-tumor cell cultures and antigen-stimulated lymphocyte cultures have augmented NK activity. It is important to know whether the effect of OK432 is on already mature NK cells or pre-NK cells. It is observed that carcinomatous pleural effusions of cancer patients contain adherent cells that suppress the maintenance and development of NK activity. OK432 enhanced NK activity regardless of the presence of adherent suppressor cells. Effusion lymphocytes were activated by OK432 but not by IFN." @default.
- W77605619 created "2016-06-24" @default.
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- W77605619 date "1982-01-01" @default.
- W77605619 modified "2023-09-25" @default.
- W77605619 title "AUGMENTATION OF HUMAN NATURAL KILLING ACTIVITY BY OK432" @default.
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- W77605619 doi "https://doi.org/10.1016/b978-0-12-341360-4.50071-8" @default.
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