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- W776401844 abstract "The eukaryotic cell consists of a large system of membrane delimited compartments. Material exchange between these compartments is mediated by intracellular trafficking vesicles. These vesicles bud from a donor compartment, travel along the cytoskeleton, are tethered, and finally fuse with the membrane of the target compartment. Several key protein families (e.g. SNARE, SNAP, Rab, SM, C2 domain proteins) that are involved in intracellular trafficking are highly conserved not only between species, but also between different trafficking steps. The precise molecular activity of the members of these families is often not well understood and little is currently known about the changes of individual factors during evolution. Unraveling the evolutionary history of these vesicular fusion proteins would fill the gaps and provide more insight into the molecular events. Hence, a technical basis is needed for data handling and to conduct necessary analyses. This thesis describes the development of the highly flexible and efficient Tracey management system (database, Java database package, and web interface). With this innovative system, it is possible to classify and analyze even extremely complex and versatile protein families. Consequently, the system was used to analyzed SNARE proteins in fungi, the SNAP family, and C2 domains in fungi." @default.
- W776401844 created "2016-06-24" @default.
- W776401844 creator A5091176534 @default.
- W776401844 date "2010-10-01" @default.
- W776401844 modified "2023-09-23" @default.
- W776401844 title "Phylogenetic studies of the vesicular fusion machinery" @default.
- W776401844 hasPublicationYear "2010" @default.
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