FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W776641331> ?p ?o ?g. }

• W776641331 endingPage "219" @default.
• W776641331 startingPage "211" @default.
• W776641331 abstract "The type 1 equilibrative nucleoside transporter (ENT1) is implicated in regulating levels of extracellular adenosine ([AD]ex). In the basal forebrain (BF) levels of [AD]ex increase during wakefulness and closely correspond to the increases in the electroencephalogram (EEG) delta (0.75-4.5Hz) activity (NRδ) during subsequent non-rapid eye movement sleep (NREMS). Thus in the BF, [AD]ex serves as a biochemical marker of sleep homeostasis. Waking EEG activity in theta range (5-9Hz, Wθ) is also described as a marker of sleep homeostasis. An hour-by-hour temporal relationship between the Wθ and NRδ is unclear. In this study we examined the relationship between these EEG markers of sleep homeostasis during spontaneous sleep-wakefulness and during sleep deprivation (SD) and recovery sleep in the ENT1 gene knockout (ENT1KO) mouse. We observed that baseline NREMS amount was decreased during the light period in ENT1KO mice, accompanied by a weak correlation between Wθ of each hour and NRδ of its subsequent hour when compared to their wild-type (WT) littermates. Perfusion of low dose of adenosine into BF not only strengthened the Wθ-NRδ relationship, but also increased NREMS to match with the WT littermates suggesting decreased [AD]ex in ENT1KO mice. However, the SD-induced [AD]ex increase in the BF and the linear correlation between the EEG markers of sleep homeostasis were unaffected in ENT1KO mice suggesting that during SD, sources other than ENT1 contribute to increase in [AD]ex. Our data provide evidence for a differential regulation of wakefulness-associated [AD]ex during spontaneous vs prolonged waking." @default.
• W776641331 created "2016-06-24" @default.
• W776641331 creator A5002161927 @default.
• W776641331 creator A5014397379 @default.
• W776641331 creator A5040186991 @default.
• W776641331 creator A5051091059 @default.
• W776641331 creator A5075560322 @default.
• W776641331 creator A5083436505 @default.
• W776641331 creator A5088598537 @default.
• W776641331 date "2015-09-01" @default.
• W776641331 modified "2023-10-09" @default.
• W776641331 title "Disrupted sleep–wake regulation in type 1 equilibrative nucleoside transporter knockout mice" @default.
• W776641331 cites W131366905 @default.
• W776641331 cites W1827370280 @default.
• W776641331 cites W1882362584 @default.
• W776641331 cites W1973343893 @default.
• W776641331 cites W1975921630 @default.
• W776641331 cites W1977186303 @default.
• W776641331 cites W1977589043 @default.
• W776641331 cites W1990291419 @default.
• W776641331 cites W1992633305 @default.
• W776641331 cites W2000693195 @default.
• W776641331 cites W2005155588 @default.
• W776641331 cites W2009562654 @default.
• W776641331 cites W2010152657 @default.
• W776641331 cites W2011558048 @default.
• W776641331 cites W2021589497 @default.
• W776641331 cites W2022844399 @default.
• W776641331 cites W2032369610 @default.
• W776641331 cites W2037573884 @default.
• W776641331 cites W2045815714 @default.
• W776641331 cites W2053651413 @default.
• W776641331 cites W2055803044 @default.
• W776641331 cites W2065428236 @default.
• W776641331 cites W2066776462 @default.
• W776641331 cites W2083143366 @default.
• W776641331 cites W2088810211 @default.
• W776641331 cites W2090240067 @default.
• W776641331 cites W2107277218 @default.
• W776641331 cites W2115576097 @default.
• W776641331 cites W2120144854 @default.
• W776641331 cites W2125337181 @default.
• W776641331 cites W2145758516 @default.
• W776641331 cites W2171349294 @default.
• W776641331 cites W2192080449 @default.
• W776641331 cites W2411632744 @default.
• W776641331 doi "https://doi.org/10.1016/j.neuroscience.2015.06.037" @default.
• W776641331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4532636" @default.
• W776641331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26143012" @default.
• W776641331 hasPublicationYear "2015" @default.
• W776641331 type Work @default.
• W776641331 sameAs 776641331 @default.
• W776641331 citedByCount "21" @default.
• W776641331 countsByYear W7766413312016 @default.
• W776641331 countsByYear W7766413312017 @default.
• W776641331 countsByYear W7766413312018 @default.
• W776641331 countsByYear W7766413312019 @default.
• W776641331 countsByYear W7766413312020 @default.
• W776641331 countsByYear W7766413312021 @default.
• W776641331 countsByYear W7766413312022 @default.
• W776641331 crossrefType "journal-article" @default.
• W776641331 hasAuthorship W776641331A5002161927 @default.
• W776641331 hasAuthorship W776641331A5014397379 @default.
• W776641331 hasAuthorship W776641331A5040186991 @default.
• W776641331 hasAuthorship W776641331A5051091059 @default.
• W776641331 hasAuthorship W776641331A5075560322 @default.
• W776641331 hasAuthorship W776641331A5083436505 @default.
• W776641331 hasAuthorship W776641331A5088598537 @default.
• W776641331 hasBestOaLocation W7766413312 @default.
• W776641331 hasConcept C111919701 @default.
• W776641331 hasConcept C121446783 @default.
• W776641331 hasConcept C126322002 @default.
• W776641331 hasConcept C134018914 @default.
• W776641331 hasConcept C169760540 @default.
• W776641331 hasConcept C170493617 @default.
• W776641331 hasConcept C182704531 @default.
• W776641331 hasConcept C207001950 @default.
• W776641331 hasConcept C26291073 @default.
• W776641331 hasConcept C2775841894 @default.
• W776641331 hasConcept C2776287375 @default.
• W776641331 hasConcept C2776991684 @default.
• W776641331 hasConcept C2778329153 @default.
• W776641331 hasConcept C2779213384 @default.
• W776641331 hasConcept C2779320081 @default.
• W776641331 hasConcept C41008148 @default.
• W776641331 hasConcept C522805319 @default.
• W776641331 hasConcept C529278444 @default.
• W776641331 hasConcept C54355233 @default.
• W776641331 hasConcept C63645605 @default.
• W776641331 hasConcept C71924100 @default.
• W776641331 hasConcept C86803240 @default.
• W776641331 hasConceptScore W776641331C111919701 @default.
• W776641331 hasConceptScore W776641331C121446783 @default.
• W776641331 hasConceptScore W776641331C126322002 @default.
• W776641331 hasConceptScore W776641331C134018914 @default.
• W776641331 hasConceptScore W776641331C169760540 @default.
• W776641331 hasConceptScore W776641331C170493617 @default.
• W776641331 hasConceptScore W776641331C182704531 @default.

• next