Matches in SemOpenAlex for { <https://semopenalex.org/work/W7773143> ?p ?o ?g. }
- W7773143 endingPage "490" @default.
- W7773143 startingPage "479" @default.
- W7773143 abstract "Gene delivery to cancer has been hindered by inefficacy of vectors delivered via the systemic route. The use of bacteriophages (phage) in targeting strategies is an attractive alternative. The power of phage display-mediated targeting to the tumor vasculature has also been combined with the integration of genomic cis elements of adeno-associated virus (AAV2), resulting in eukaryotic/prokaryotic hybrid vectors termed AAV/phage (AAVP). To facilitate targeting of cancer cells as well as associated endothelium, the well-established double cyclic RGD (CDCRGDCFC, termed RGD4C) motif, which binds to αv integrin receptors upregulated in the angiogenic blood vessels of tumors, was displayed on the bacteriophage capsid. As a proof of concept, the tissue specificity and efficiency of transgene delivery and expression after systemic administration was confirmed using several animal models of cancer. In vivo imaging of reporter genes was performed using bioluminescence imaging and positron emission tomography. This chapter highlights the potential of tumor-targeted AAVP vector to enhance the effectiveness of systemic gene therapy and genetic imaging modalities." @default.
- W7773143 created "2016-06-24" @default.
- W7773143 creator A5002937598 @default.
- W7773143 creator A5040671188 @default.
- W7773143 creator A5066477647 @default.
- W7773143 creator A5071646635 @default.
- W7773143 date "2014-01-01" @default.
- W7773143 modified "2023-09-25" @default.
- W7773143 title "Bacteriophage" @default.
- W7773143 cites W1497912720 @default.
- W7773143 cites W1534345338 @default.
- W7773143 cites W1559562147 @default.
- W7773143 cites W1576210721 @default.
- W7773143 cites W1587050401 @default.
- W7773143 cites W1591942886 @default.
- W7773143 cites W1604428153 @default.
- W7773143 cites W1907702585 @default.
- W7773143 cites W1966687379 @default.
- W7773143 cites W1971765006 @default.
- W7773143 cites W1975515428 @default.
- W7773143 cites W1978076167 @default.
- W7773143 cites W1979838211 @default.
- W7773143 cites W1983814380 @default.
- W7773143 cites W1985804036 @default.
- W7773143 cites W1986354324 @default.
- W7773143 cites W1987746867 @default.
- W7773143 cites W1987793423 @default.
- W7773143 cites W1988177186 @default.
- W7773143 cites W1994216715 @default.
- W7773143 cites W1994284515 @default.
- W7773143 cites W1994977520 @default.
- W7773143 cites W1996100284 @default.
- W7773143 cites W1999600810 @default.
- W7773143 cites W1999625705 @default.
- W7773143 cites W2000000541 @default.
- W7773143 cites W2001064152 @default.
- W7773143 cites W2001728487 @default.
- W7773143 cites W2001753204 @default.
- W7773143 cites W2002230528 @default.
- W7773143 cites W2002398030 @default.
- W7773143 cites W2003145314 @default.
- W7773143 cites W2006534560 @default.
- W7773143 cites W2010502399 @default.
- W7773143 cites W2014356856 @default.
- W7773143 cites W2015615249 @default.
- W7773143 cites W2017193849 @default.
- W7773143 cites W2018174215 @default.
- W7773143 cites W2024078329 @default.
- W7773143 cites W2025314170 @default.
- W7773143 cites W2025793830 @default.
- W7773143 cites W2028261802 @default.
- W7773143 cites W2030973598 @default.
- W7773143 cites W2031630601 @default.
- W7773143 cites W2033689077 @default.
- W7773143 cites W2033697559 @default.
- W7773143 cites W2034421909 @default.
- W7773143 cites W2034481110 @default.
- W7773143 cites W2038575932 @default.
- W7773143 cites W2042259141 @default.
- W7773143 cites W2045702474 @default.
- W7773143 cites W2049093417 @default.
- W7773143 cites W2049109647 @default.
- W7773143 cites W2050085273 @default.
- W7773143 cites W2057535231 @default.
- W7773143 cites W2057955115 @default.
- W7773143 cites W2066503773 @default.
- W7773143 cites W2070415473 @default.
- W7773143 cites W2070897329 @default.
- W7773143 cites W2071854673 @default.
- W7773143 cites W2075399589 @default.
- W7773143 cites W2078251729 @default.
- W7773143 cites W2083982701 @default.
- W7773143 cites W2084220221 @default.
- W7773143 cites W2084693381 @default.
- W7773143 cites W2085496006 @default.
- W7773143 cites W2090256568 @default.
- W7773143 cites W2091602327 @default.
- W7773143 cites W2092160349 @default.
- W7773143 cites W2092475807 @default.
- W7773143 cites W2094773831 @default.
- W7773143 cites W2104619616 @default.
- W7773143 cites W2112041130 @default.
- W7773143 cites W2113813607 @default.
- W7773143 cites W2118590366 @default.
- W7773143 cites W2126331514 @default.
- W7773143 cites W2129695436 @default.
- W7773143 cites W2133308954 @default.
- W7773143 cites W2139964006 @default.
- W7773143 cites W2141162905 @default.
- W7773143 cites W2152136726 @default.
- W7773143 cites W2153138904 @default.
- W7773143 cites W2153381032 @default.
- W7773143 cites W2159725525 @default.
- W7773143 cites W2164501001 @default.
- W7773143 cites W2170556702 @default.
- W7773143 cites W2804842145 @default.
- W7773143 cites W3102414871 @default.
- W7773143 cites W4253384929 @default.