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• W777563007 abstract "Objective: The purpose of this study was to evaluate the potential for oral sustained delivery of ofloxacin. The plasma half-life of ofloxacin was 4 hrs and dose was 200-800mg twice/thrice a day depending on severity of infection. Dose >400mg was given in two divided dose. Hence ofloxacin was chosen as a model drug with an aim to develop a sustained release system for 16 hrs. Experimental Method: Oral administration of aqueous solution of sodium alginate (1% w/v) containing calcium ion (1.5% w/v) in complexed form resulted in formulation of gel. The effects of different concentration of sodium alginate and calcium carbonate on viscosity and drug release at 10 hrs (% Q10) were studied using 3 2 factorial designs. The prepared formulation  were evaluated  for various parameter like floating lag time, total floating time, pH, gelling time and gelling capacity, swelling index, drug content and in-vitro  drug release. The optimized formulation was subjected to stability study for 1 month." @default.
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• W777563007 date "2013-08-30" @default.
• W777563007 modified "2023-09-28" @default.
• W777563007 title "Formulation & Evaluation of Floatable In-situ Gel for Stomach-specific Drug Delivery of Ofloxacin" @default.
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