Matches in SemOpenAlex for { <https://semopenalex.org/work/W77761105> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W77761105 endingPage "42" @default.
- W77761105 startingPage "327" @default.
- W77761105 abstract "Excessive manganese (Mn) has been associated with neurobehavioral deficits and neurological and/or neuropsychiatric illness, but the level at which this metal can cause adverse neurotoxic effects, particularly with long-term exposure, is still unknown. The objective of the present study was to assess nervous system functions in residents exposed to manganese from a variety of environmental sources. A random stratified sampling procedure was used to select participants; persons with a history of workplace exposure to Mn and other neurotoxic substances were excluded. A self-administered questionnaire provided data on socio-demographic variables. Blood samples were analyzed for total manganese (MnB), lead, mercury and serum iron. Nervous system assessment included computer and hand-administered neurobehavioral tests, computerized neuromotor tests, sensory evaluation and a neurological examination. The present analyses include 273 persons (151 women and 122 men); MnB range: 2.5 micrograms/L-15.9 micrograms/L (median: 7.3 micrograms/L). Multivariate analyses were used and neuro-outcomes were examined with respect to MnB, taking into account potential confounders and covariables. Results were grouped according to neurofunctional areas and MANOVA analyses revealed that higher MnB (7.5 micrograms/L) was significantly associated with changes in coordinated upper limb movements (Wilks' lambda = 0.92; p = 0.04) and poorer learning and recall (men: Wilks' lambda = 0.77; p = 0.002; women: Wilks' lambda = 0.86; p = 0.04). Further analyses revealed that with increasing log MnB (Simple regression: p < 0.05) performance on a pointing task was poorer, frequency dispersion of hand-arm tremor decreased, while harmonic index increased, and the velocity of a pronation/supination arm movement was slower. An Mn-age interaction was observed for certain motor tasks, with the poorest performance observed among those _50 y and in the higher MnB category. Differences between genders suggest that men may be at greater risk than women, although effects were also observed in women. These findings are consistent with the hypothesis that Mn neurotoxicity can be viewed on a continuum of dysfunction, with early, subtle changes at lower exposure levels." @default.
- W77761105 created "2016-06-24" @default.
- W77761105 creator A5010314174 @default.
- W77761105 creator A5014494445 @default.
- W77761105 creator A5027475224 @default.
- W77761105 creator A5030418706 @default.
- W77761105 creator A5040806633 @default.
- W77761105 creator A5056190390 @default.
- W77761105 creator A5064992089 @default.
- W77761105 creator A5074127933 @default.
- W77761105 creator A5078767342 @default.
- W77761105 creator A5083689586 @default.
- W77761105 creator A5006508958 @default.
- W77761105 date "1999-07-01" @default.
- W77761105 modified "2023-10-01" @default.
- W77761105 title "Manganese neurotoxicity, a continuum of dysfunction: results from a community based study." @default.
- W77761105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10385894" @default.
- W77761105 hasPublicationYear "1999" @default.
- W77761105 type Work @default.
- W77761105 sameAs 77761105 @default.
- W77761105 citedByCount "74" @default.
- W77761105 countsByYear W777611052012 @default.
- W77761105 countsByYear W777611052013 @default.
- W77761105 countsByYear W777611052014 @default.
- W77761105 countsByYear W777611052015 @default.
- W77761105 countsByYear W777611052016 @default.
- W77761105 countsByYear W777611052017 @default.
- W77761105 countsByYear W777611052018 @default.
- W77761105 countsByYear W777611052020 @default.
- W77761105 countsByYear W777611052021 @default.
- W77761105 countsByYear W777611052022 @default.
- W77761105 countsByYear W777611052023 @default.
- W77761105 crossrefType "journal-article" @default.
- W77761105 hasAuthorship W77761105A5006508958 @default.
- W77761105 hasAuthorship W77761105A5010314174 @default.
- W77761105 hasAuthorship W77761105A5014494445 @default.
- W77761105 hasAuthorship W77761105A5027475224 @default.
- W77761105 hasAuthorship W77761105A5030418706 @default.
- W77761105 hasAuthorship W77761105A5040806633 @default.
- W77761105 hasAuthorship W77761105A5056190390 @default.
- W77761105 hasAuthorship W77761105A5064992089 @default.
- W77761105 hasAuthorship W77761105A5074127933 @default.
- W77761105 hasAuthorship W77761105A5078767342 @default.
- W77761105 hasAuthorship W77761105A5083689586 @default.
- W77761105 hasConcept C126322002 @default.
- W77761105 hasConcept C15744967 @default.
- W77761105 hasConcept C2779491297 @default.
- W77761105 hasConcept C29730261 @default.
- W77761105 hasConcept C71924100 @default.
- W77761105 hasConcept C77350462 @default.
- W77761105 hasConcept C99476002 @default.
- W77761105 hasConceptScore W77761105C126322002 @default.
- W77761105 hasConceptScore W77761105C15744967 @default.
- W77761105 hasConceptScore W77761105C2779491297 @default.
- W77761105 hasConceptScore W77761105C29730261 @default.
- W77761105 hasConceptScore W77761105C71924100 @default.
- W77761105 hasConceptScore W77761105C77350462 @default.
- W77761105 hasConceptScore W77761105C99476002 @default.
- W77761105 hasIssue "2-3" @default.
- W77761105 hasLocation W777611051 @default.
- W77761105 hasOpenAccess W77761105 @default.
- W77761105 hasPrimaryLocation W777611051 @default.
- W77761105 hasRelatedWork W1965832271 @default.
- W77761105 hasRelatedWork W1991143793 @default.
- W77761105 hasRelatedWork W2065146251 @default.
- W77761105 hasRelatedWork W2185923119 @default.
- W77761105 hasRelatedWork W2586035548 @default.
- W77761105 hasRelatedWork W2593167222 @default.
- W77761105 hasRelatedWork W2792062212 @default.
- W77761105 hasRelatedWork W2913642592 @default.
- W77761105 hasRelatedWork W3029422704 @default.
- W77761105 hasRelatedWork W77761105 @default.
- W77761105 hasVolume "20" @default.
- W77761105 isParatext "false" @default.
- W77761105 isRetracted "false" @default.
- W77761105 magId "77761105" @default.
- W77761105 workType "article" @default.