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- W777743725 abstract "MODULATION OF THE SEROTONIN REUPTAKE TRANSPORTER IN RAW264.7 MACROPHAGES Sienna Marie Arenas Malubay, B.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2006 Major Director: Jennifer K. Stewart, Ph.D., Associate Professor, Department of Biology Serotonin (5-HT) plays an important role as both a neurotransmitter and an immune modulator. The serotonin reuptake transporter (SERT) clears the extracellular space of 5-HT, which decreases the effects of 5-HT on target cells. This study demonstrated that the RAW264.7 macrophage cell line expresses SERT function, measured by assays of 3 ~ 5 ~ ~ uptake. The 5-HT uptake in RAW264.7 macrophages was more than 10-fold that of peritoneal macrophages, indicating that these cells are an excellent model for studying regulation of the SERT. Activation of macrophages with xii lipopolysaccharide (LPS) increased SERT activity in a timeand concentrationdependent manner and Western blots indicate that the increase in activity is partially due to LPS-induced increases in total SERT protein. Both unstimulated and LPS-stimulated activity was inhibited by the specific SERT inhibitor fluoxetine (ICSo = 5-8 nM) and was reduced by the anti-inflammatory cytokine interleulun-10. Changes in extracellular concentrations of interleulun-lp and tumor necrosis factor-a did not affect SERT activity." @default.
- W777743725 created "2016-06-24" @default.
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- W777743725 date "2006-01-01" @default.
- W777743725 modified "2023-09-23" @default.
- W777743725 title "Modulation of the Serotonin Reuptake Transporter in RAW264.7 Macrophages" @default.
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- W777743725 doi "https://doi.org/10.25772/mhwd-s410" @default.
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