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- W77774799 abstract "The genetic mechanism of MHC polymorphism generation is a controversial issue and it has been supposed to vary from locus to locus [1,2]. Recombination mechanisms (gene duplication, gene conversion, inter-allelic/inter-locus sequence exchange) and point mutations are thought to have played different roles during the evolution of the various HLA class II loci [3–5]. In this respect, recombination events promoted by conserved χ-like putative recombination signals, found in HLA-DRB 1 and -DPB 1 genes between the β-sheet and α-helix domains, are believed to have significantly contributed to polymorphism generation at these loci [5,6]. By contrast, the fact that χ-like sequences have not been observed at the DQB1 locus has been put forward to explain why recombination-like events are less frequently seen at this locus where point mutations are considered to have played the major role in polymorphism generation [1]. We indicate that a χ-like sequence is also present within the DQB1 locus (5’-GCTGGGG-3’, nucleotide position 156–162) and that this motif may have contributed, through intralocus gene conversion, to the generation of the novel DQB 1 *0305 allele." @default.
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- W77774799 date "1994-01-01" @default.
- W77774799 modified "2023-10-18" @default.
- W77774799 title "Molecular Analysis of a Novel HLA-DQB1 Allele and Its Gene Frequency Among Sardinians" @default.
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- W77774799 doi "https://doi.org/10.1007/978-3-642-78782-9_111" @default.
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