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- W77797553 abstract "We previously demonstrated that dairy components (calcium, leucine, and dairy peptides) suppress adipocyte and macrophage-mediated oxidative and inflammatory stress. Since oxidative and inflammatory burdens are magnified in metabolic syndrome, we have assessed the effects of low (<0.5 servings) vs. adequate (3.5 servings) dairy (LD vs. AD) diets on oxidative and inflammatory stress in the absence of caloric restriction in 40 metabolic syndrome subjects with habitually low dairy intakes. Diet had no effect on body weight over the 12-week study, but AD significantly reduced waist circumference and DXA-measured trunk fat (p<0.01 for both), while LD had no effect. AD attenuated oxidative stress, with a 35% decrease in MDA evident at 7 days (p<0.01) and maintained through 12 weeks and a progressive decrease in oxidized LDL evident at 7 days (11%) and progressing to a 25% decrease at 12 weeks (p<0.01), while LD had no effect. Similarly, inflammatory markers were suppressed by AD, with decreases in TNF-&α evident at seven days and further reductions through 12 weeks (35%, p<0.05), IL-6 (21%, p<0.02), MCP-1 (14% drop at four weeks, 24% drop at 12 weeks, p<0.05), and a corresponding 55% increase in adiponectin (55% at 12 weeks, p<0.01). LD exerted no effect on these markers. Thus, increasing dairy intake results in attenuation of oxidative and inflammatory stress in metabolic syndrome. Supported by the National Dairy Council." @default.
- W77797553 created "2016-06-24" @default.
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- W77797553 date "2010-04-01" @default.
- W77797553 modified "2023-09-27" @default.
- W77797553 title "Dairy attenuation of oxidative and inflammatory stress in metabolic syndrome" @default.
- W77797553 doi "https://doi.org/10.1096/fasebj.24.1_supplement.105.3" @default.
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