FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W77866970> ?p ?o ?g. }

• W77866970 endingPage "3421" @default.
• W77866970 startingPage "3414" @default.
• W77866970 abstract "Abstract The marrow repopulating potential (MRP) of different sources of human hematopoietic stem cells (HSCs) was directly compared using an in vivo assay in which severe combined immunodeficient disease (SCID) mice were implanted with human fetal bones. HSCs from 2 human lymphocyte antigen (HLA)-mismatched donors were injected individually or simultaneously into the fetal bones of a 3rd distinct HLA type and donor and recipient myeloid and lymphoid cells were identified after 8 to 10 weeks. The study compared the MRP of umbilical cord blood (CB) and adult bone marrow (ABM) CD34+ cells as well as grafts of each type expanded ex vivo. Equal numbers of CB and ABM CD34+ cells injected individually demonstrated similar abilities to establish multilineage hematopoiesis. However, when CB and ABM cells were transplanted simultaneously, the engraftment of CB cells was markedly superior to ABM. CB and ABM CD34+ cells were expanded ex vivo using either a porcine microvascular endothelial cell (PMVEC)-based coculture system or a stroma-free expansion system. Primary CB CD34+ cells or CD34+ cells expanded in either culture system demonstrated a similar ability to engraft. However, the MRP of expanded grafts simultaneously injected with primary CB cells was uniformly inferior to primary CB cells. CD34+ cell grafts expanded in the stroma-free system, furthermore, outcompeted CD34+ cells expanded using the PMVEC coculture system. The triple HLA-mismatched SCID-hu model represents a novel in vivo stem cell assay system that permits the direct demonstration of the functional consequences of ex vivo HSC expansion and ontogeny-related differences in HSCs." @default.
• W77866970 created "2016-06-24" @default.
• W77866970 creator A5006372952 @default.
• W77866970 creator A5011591643 @default.
• W77866970 creator A5028575955 @default.
• W77866970 creator A5083678047 @default.
• W77866970 date "2000-11-15" @default.
• W77866970 modified "2023-10-16" @default.
• W77866970 title "An in vivo competitive repopulation assay for various sources of human hematopoietic stem cells" @default.
• W77866970 cites W126539919 @default.
• W77866970 cites W1512478116 @default.
• W77866970 cites W153436937 @default.
• W77866970 cites W173907651 @default.
• W77866970 cites W190201512 @default.
• W77866970 cites W1955659593 @default.
• W77866970 cites W1976525396 @default.
• W77866970 cites W1981441452 @default.
• W77866970 cites W2016110433 @default.
• W77866970 cites W2024939366 @default.
• W77866970 cites W2040827928 @default.
• W77866970 cites W2042998709 @default.
• W77866970 cites W2058875293 @default.
• W77866970 cites W2059626630 @default.
• W77866970 cites W2084256703 @default.
• W77866970 cites W2085516849 @default.
• W77866970 cites W2097857054 @default.
• W77866970 cites W2110116124 @default.
• W77866970 cites W2115833446 @default.
• W77866970 cites W2129321368 @default.
• W77866970 cites W2132925264 @default.
• W77866970 cites W2147654197 @default.
• W77866970 cites W2175016040 @default.
• W77866970 cites W2240289126 @default.
• W77866970 cites W2243479910 @default.
• W77866970 cites W2272909078 @default.
• W77866970 cites W2277156053 @default.
• W77866970 cites W2285961883 @default.
• W77866970 cites W2318851296 @default.
• W77866970 cites W2330713242 @default.
• W77866970 cites W2333162405 @default.
• W77866970 cites W2338319247 @default.
• W77866970 cites W2354001511 @default.
• W77866970 cites W2408312506 @default.
• W77866970 cites W261120209 @default.
• W77866970 cites W29953550 @default.
• W77866970 cites W35113883 @default.
• W77866970 cites W4241625350 @default.
• W77866970 cites W4252005937 @default.
• W77866970 cites W4254579396 @default.
• W77866970 cites W597759872 @default.
• W77866970 cites W80850850 @default.
• W77866970 cites W9231455 @default.
• W77866970 doi "https://doi.org/10.1182/blood.v96.10.3414" @default.
• W77866970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11071636" @default.
• W77866970 hasPublicationYear "2000" @default.
• W77866970 type Work @default.
• W77866970 sameAs 77866970 @default.
• W77866970 citedByCount "45" @default.
• W77866970 countsByYear W778669702012 @default.
• W77866970 countsByYear W778669702013 @default.
• W77866970 countsByYear W778669702014 @default.
• W77866970 countsByYear W778669702016 @default.
• W77866970 countsByYear W778669702017 @default.
• W77866970 countsByYear W778669702018 @default.
• W77866970 countsByYear W778669702020 @default.
• W77866970 countsByYear W778669702022 @default.
• W77866970 crossrefType "journal-article" @default.
• W77866970 hasAuthorship W77866970A5006372952 @default.
• W77866970 hasAuthorship W77866970A5011591643 @default.
• W77866970 hasAuthorship W77866970A5028575955 @default.
• W77866970 hasAuthorship W77866970A5083678047 @default.
• W77866970 hasConcept C10205521 @default.
• W77866970 hasConcept C109159458 @default.
• W77866970 hasConcept C153911025 @default.
• W77866970 hasConcept C16930146 @default.
• W77866970 hasConcept C203014093 @default.
• W77866970 hasConcept C207001950 @default.
• W77866970 hasConcept C26291073 @default.
• W77866970 hasConcept C2778086970 @default.
• W77866970 hasConcept C2779282312 @default.
• W77866970 hasConcept C2780007613 @default.
• W77866970 hasConcept C28328180 @default.
• W77866970 hasConcept C502942594 @default.
• W77866970 hasConcept C54355233 @default.
• W77866970 hasConcept C86803240 @default.
• W77866970 hasConcept C95444343 @default.
• W77866970 hasConceptScore W77866970C10205521 @default.
• W77866970 hasConceptScore W77866970C109159458 @default.
• W77866970 hasConceptScore W77866970C153911025 @default.
• W77866970 hasConceptScore W77866970C16930146 @default.
• W77866970 hasConceptScore W77866970C203014093 @default.
• W77866970 hasConceptScore W77866970C207001950 @default.
• W77866970 hasConceptScore W77866970C26291073 @default.
• W77866970 hasConceptScore W77866970C2778086970 @default.
• W77866970 hasConceptScore W77866970C2779282312 @default.
• W77866970 hasConceptScore W77866970C2780007613 @default.
• W77866970 hasConceptScore W77866970C28328180 @default.
• W77866970 hasConceptScore W77866970C502942594 @default.

• next