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- W7789262 abstract "Terminal deoxynucleotidyl transferase (TdT) is a unique DNA synthetic enzyme whose expression in normal cells is restricted to subsets of primitive lymphocytes, and among neoplastic cells is found only in the blast cells of some forms of acute leukemia and diffuse lymphoma [1–5]. This polymerase has achieved increasing attention over the last several years from both basic biologists and physicians caring for patients with malignant hematologic disease. For biologists it has emerged as a useful biochemical marker for subsets of pre-B and pre-T cells, and has played an important role in studies aimed at dissecting the ontogeny of the lymphoid system [6, 7]. In clinical medicine, blast cell TdT assays have been shown to be useful in the subclassification of acute leukemias and diffuse lymphomas, and TdT status has been used to assign patients to therapeutically meaningful categories [8, 9]." @default.
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- W7789262 date "1983-01-01" @default.
- W7789262 modified "2023-10-17" @default.
- W7789262 title "Selective Killing of Leukemia Cells by Inhibition of TdT" @default.
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- W7789262 doi "https://doi.org/10.1007/978-3-642-68761-7_4" @default.
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