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- W779074516 abstract "Multiple myeloma (MM) is a plasma cell neoplasm which constitutes about 10% of all hematologic malignancies and has been in the limelight of fast-track development of novel drugs that have contributed to the transformation of a rapidly lethal disease into a chronic illness with significant improvement in quality of life. Nonetheless, MM remains an incurable disease in many patients. Immunotherapy has been one of the approaches that had the highest hope for curing this disease. More than two decades of research and clinical trials in immunotherapy for MM have however resulted in very little impact on patient survival. The various immunotherapy approaches that have been attempted over the last two decades but were fraught with failure have already been extensively summarized in many published reviews. Nevertheless, in view of better understanding of the immune checkpoints, the innate immune system, and improved biotechnology, there is renewed hope. In this review, we will briefly discuss the unsuccessful approaches and emphasize the lessons learned, highlight the challenges that lie ahead, and discuss the more promising approaches, that already exist or being developed such as use of allogeneic stem cell transplants (allo-SCT) as a form of cellular immunotherapy, new monoclonal antibodies, chimeric antigen receptor (CAR) T-cell adoptive therapy, and NK cell therapy." @default.
- W779074516 created "2016-06-24" @default.
- W779074516 creator A5017056661 @default.
- W779074516 creator A5021737351 @default.
- W779074516 creator A5087573996 @default.
- W779074516 date "2015-12-01" @default.
- W779074516 modified "2023-10-13" @default.
- W779074516 title "Immunotherapy for multiple myeloma: Current status and future directions" @default.
- W779074516 cites W1495399084 @default.
- W779074516 cites W1524905787 @default.
- W779074516 cites W1529340407 @default.
- W779074516 cites W1571796034 @default.
- W779074516 cites W1889456951 @default.
- W779074516 cites W1913614716 @default.
- W779074516 cites W1950373871 @default.
- W779074516 cites W1963666648 @default.
- W779074516 cites W1965249739 @default.
- W779074516 cites W1969349875 @default.
- W779074516 cites W1973223101 @default.
- W779074516 cites W1975083734 @default.
- W779074516 cites W1978032636 @default.
- W779074516 cites W1980751982 @default.
- W779074516 cites W1983305922 @default.
- W779074516 cites W1984534203 @default.
- W779074516 cites W1984814515 @default.
- W779074516 cites W1988264764 @default.
- W779074516 cites W1992443497 @default.
- W779074516 cites W1994032414 @default.
- W779074516 cites W1994336777 @default.
- W779074516 cites W1995120586 @default.
- W779074516 cites W1995224930 @default.
- W779074516 cites W1995669533 @default.
- W779074516 cites W1996046011 @default.
- W779074516 cites W1997849135 @default.
- W779074516 cites W2000130439 @default.
- W779074516 cites W2001177982 @default.
- W779074516 cites W2001692330 @default.
- W779074516 cites W2004543856 @default.
- W779074516 cites W2007744512 @default.
- W779074516 cites W2009140079 @default.
- W779074516 cites W2010181990 @default.
- W779074516 cites W2010766702 @default.
- W779074516 cites W2011582582 @default.
- W779074516 cites W2012714210 @default.
- W779074516 cites W2014853459 @default.
- W779074516 cites W2015451788 @default.
- W779074516 cites W2015912224 @default.
- W779074516 cites W2016969330 @default.
- W779074516 cites W2017357058 @default.
- W779074516 cites W2018478612 @default.
- W779074516 cites W2018922991 @default.
- W779074516 cites W2020793885 @default.
- W779074516 cites W2021588881 @default.
- W779074516 cites W2022501656 @default.
- W779074516 cites W2022580424 @default.
- W779074516 cites W2022861980 @default.
- W779074516 cites W2023068069 @default.
- W779074516 cites W2023985105 @default.
- W779074516 cites W2024520647 @default.
- W779074516 cites W2024733207 @default.
- W779074516 cites W2025141198 @default.
- W779074516 cites W2025672197 @default.
- W779074516 cites W2025807829 @default.
- W779074516 cites W2028230388 @default.
- W779074516 cites W2029340932 @default.
- W779074516 cites W2030522563 @default.
- W779074516 cites W2031112746 @default.
- W779074516 cites W2035571771 @default.
- W779074516 cites W2035735851 @default.
- W779074516 cites W2038414910 @default.
- W779074516 cites W2038710845 @default.
- W779074516 cites W2039361986 @default.
- W779074516 cites W2040245747 @default.
- W779074516 cites W2041378230 @default.
- W779074516 cites W2042662562 @default.
- W779074516 cites W2047192675 @default.
- W779074516 cites W2047994597 @default.
- W779074516 cites W2048154203 @default.
- W779074516 cites W2048720119 @default.
- W779074516 cites W2049262651 @default.
- W779074516 cites W2058788010 @default.
- W779074516 cites W2058791890 @default.
- W779074516 cites W2062223527 @default.
- W779074516 cites W2063264144 @default.
- W779074516 cites W2067219562 @default.
- W779074516 cites W2067737919 @default.
- W779074516 cites W2067881995 @default.
- W779074516 cites W2068683940 @default.
- W779074516 cites W2076692985 @default.
- W779074516 cites W2086061986 @default.
- W779074516 cites W2086870979 @default.
- W779074516 cites W2087263469 @default.
- W779074516 cites W2088174145 @default.
- W779074516 cites W2090083883 @default.
- W779074516 cites W2093654081 @default.
- W779074516 cites W2095326716 @default.
- W779074516 cites W2100165190 @default.
- W779074516 cites W2102942531 @default.