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- W779732947 abstract "Sources of arsenic exposure include air, water, and food from both natural and anthropogenic sources. Arsenic is categorized as a human carcinogen, and is associated with pleiotropic toxicities including cancers of the skin, lung, and bladder. Despite arsenic’s long recognition as a human carcinogen, the exact mechanisms of arsenicalinduced carcinogenesis are unknown. Arsenic exposure has been shown to cause DNA damage. However, because arsenic does not directly react with DNA, genotoxicity is generally considered to result from indirect mechanisms. The generation of arsenicalinduced reactive oxygen species and the inhibition of critical DNA repair systems are believed to contribute to arsenical-induced carcinogenicity. The DNA damaging effects of arsenical exposure and alterations in DNA repair processes were examined within the human bladder urothelial cell line, UROtsa, following continuous exposure to the arsenic metabolite, monomethylarsonous acid [MMA(III)]. Chronic, low-level MMA(III) exposure results in the induction of DNA damage that remains elevated following the removal of MMA(III). Furthermore, data presented herein, defines the critical period in which continuous low-level MMA(III) exposure causes the malignant transformation of the UROtsa cell line. Results indicate that malignant transformation of UROtsa cells is irreversible following 12 wk of low-level MMA(III) exposure. Assessment of the MMA(III)-induced biological alterations leading to the malignant transformation of UROtsa cells following 12 wk of exposure suggest two potential interdependent mechanisms in which MMA(III) may increase the susceptibility of UROtsa cells to" @default.
- W779732947 created "2016-06-24" @default.
- W779732947 creator A5031699453 @default.
- W779732947 date "2011-01-01" @default.
- W779732947 modified "2023-09-27" @default.
- W779732947 title "Mechanisms of malignant transformation of human urothelial cells by monomethylarsonous acid" @default.
- W779732947 cites W1000047427 @default.
- W779732947 cites W1194792455 @default.
- W779732947 cites W132371512 @default.
- W779732947 cites W1483751849 @default.
- W779732947 cites W1490148751 @default.
- W779732947 cites W1490307351 @default.
- W779732947 cites W1493881774 @default.
- W779732947 cites W1498308778 @default.
- W779732947 cites W1519731306 @default.
- W779732947 cites W1519767585 @default.
- W779732947 cites W1532318361 @default.
- W779732947 cites W1533137732 @default.
- W779732947 cites W1540963998 @default.
- W779732947 cites W1541649582 @default.
- W779732947 cites W1543546710 @default.
- W779732947 cites W1547975753 @default.
- W779732947 cites W1549011458 @default.
- W779732947 cites W1552681886 @default.
- W779732947 cites W1570879094 @default.
- W779732947 cites W1570986866 @default.
- W779732947 cites W1571583248 @default.
- W779732947 cites W1600954336 @default.
- W779732947 cites W1645990259 @default.
- W779732947 cites W1655441320 @default.
- W779732947 cites W1661180389 @default.
- W779732947 cites W1679032940 @default.
- W779732947 cites W1723613868 @default.
- W779732947 cites W1745280408 @default.
- W779732947 cites W1752932536 @default.
- W779732947 cites W176423527 @default.
- W779732947 cites W1828848048 @default.
- W779732947 cites W1853068488 @default.
- W779732947 cites W1907686361 @default.
- W779732947 cites W1933843339 @default.
- W779732947 cites W1963696871 @default.
- W779732947 cites W1964699982 @default.
- W779732947 cites W1968145127 @default.
- W779732947 cites W1968188089 @default.
- W779732947 cites W1969005700 @default.
- W779732947 cites W1970214954 @default.
- W779732947 cites W1972305678 @default.
- W779732947 cites W1972367913 @default.
- W779732947 cites W1972504105 @default.
- W779732947 cites W1973290552 @default.
- W779732947 cites W1973297589 @default.
- W779732947 cites W1973769612 @default.
- W779732947 cites W1973875276 @default.
- W779732947 cites W1974187478 @default.
- W779732947 cites W1975016344 @default.
- W779732947 cites W1975161039 @default.
- W779732947 cites W1975629656 @default.
- W779732947 cites W1976729406 @default.
- W779732947 cites W1977121274 @default.
- W779732947 cites W1977649461 @default.
- W779732947 cites W1977896790 @default.
- W779732947 cites W1979548474 @default.
- W779732947 cites W1979861889 @default.
- W779732947 cites W1980974420 @default.
- W779732947 cites W1981247000 @default.
- W779732947 cites W1982186516 @default.
- W779732947 cites W1982602899 @default.
- W779732947 cites W1983150374 @default.
- W779732947 cites W1984517892 @default.
- W779732947 cites W1985800606 @default.
- W779732947 cites W1985869400 @default.
- W779732947 cites W1987981580 @default.
- W779732947 cites W1988604509 @default.
- W779732947 cites W1990559952 @default.
- W779732947 cites W1990623204 @default.
- W779732947 cites W1991701837 @default.
- W779732947 cites W1992676492 @default.
- W779732947 cites W1993532042 @default.
- W779732947 cites W1994008801 @default.
- W779732947 cites W1995338674 @default.
- W779732947 cites W1995577291 @default.
- W779732947 cites W1996694599 @default.
- W779732947 cites W1997565776 @default.
- W779732947 cites W1999711568 @default.
- W779732947 cites W2001156156 @default.
- W779732947 cites W2001396364 @default.
- W779732947 cites W2002385818 @default.
- W779732947 cites W2002552177 @default.
- W779732947 cites W2002721333 @default.
- W779732947 cites W2003717936 @default.
- W779732947 cites W2004386304 @default.
- W779732947 cites W2004835835 @default.
- W779732947 cites W2005933510 @default.
- W779732947 cites W2006217213 @default.
- W779732947 cites W2007620375 @default.
- W779732947 cites W2007782053 @default.
- W779732947 cites W2007996640 @default.
- W779732947 cites W2008852569 @default.
- W779732947 cites W2009293759 @default.
- W779732947 cites W2009461060 @default.