Matches in SemOpenAlex for { <https://semopenalex.org/work/W7801047> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W7801047 endingPage "S41" @default.
- W7801047 startingPage "S41" @default.
- W7801047 abstract "Abstract TLR2−/− mice immunized with Streptococcus pneumoniae (Pn) have defective type 1 (IgG3, IgG2b, and IgG2a) humoral immunity, but a similar type 2 (IgG1) response relative to WT mice. Of note, this defect in adaptive immunity was associated with a largely normal innate immune response to Pn. We thus hypothesized that TLR2 plays a critical role directly at the level of the adaptive immune system. We demonstrate that CD4+ T cells from Pn-primed TLR2−/− mice elicit a normal cytokine response after in vitro re-stimulation with Pn protein. In contrast, MyD88−/− mice, exhibiting both defective innate and type 1, but elevated type 2, humoral immunity to Pn, elicit an increased type 2 cytokine response. Bone marrow dendritic cells (BMDC) from TLR2−/− mice have only a modest defect in cytokine secretion, including IL-12, and undergo normal maturation in response to Pn. TLR2−/− BMDC pulsed with Pn and transferred into WT mice elicit a normal Ig response, relative to WT BMDC. In contrast, Pn fails to costimulate in vitro proliferation of purified TLR2−/− B cells activated via multivalent B cell receptor crosslinking, while costimulating WT B cells. Adoptive transfer studies demonstrate that TLR2−/−, but not WT, B cells are defective in eliciting Ig responses to Pn in either a TLR2−/− or WT background. These data are the first to indicate a critical role for B cell expression of TLR2 during a humoral immune response to an intact bacterium. N.I.H. R01 AI49192" @default.
- W7801047 created "2016-06-24" @default.
- W7801047 creator A5042287069 @default.
- W7801047 creator A5043094911 @default.
- W7801047 creator A5063304740 @default.
- W7801047 creator A5088022555 @default.
- W7801047 date "2007-04-01" @default.
- W7801047 modified "2023-10-04" @default.
- W7801047 title "B cell expression of TLR2 is critical for optimal induction of humoral immunity to intact Streptococcus pneumoniae (43.27)" @default.
- W7801047 doi "https://doi.org/10.4049/jimmunol.178.supp.43.27" @default.
- W7801047 hasPublicationYear "2007" @default.
- W7801047 type Work @default.
- W7801047 sameAs 7801047 @default.
- W7801047 citedByCount "1" @default.
- W7801047 crossrefType "journal-article" @default.
- W7801047 hasAuthorship W7801047A5042287069 @default.
- W7801047 hasAuthorship W7801047A5043094911 @default.
- W7801047 hasAuthorship W7801047A5063304740 @default.
- W7801047 hasAuthorship W7801047A5088022555 @default.
- W7801047 hasConcept C136449434 @default.
- W7801047 hasConcept C159654299 @default.
- W7801047 hasConcept C193419808 @default.
- W7801047 hasConcept C203014093 @default.
- W7801047 hasConcept C2776548049 @default.
- W7801047 hasConcept C2778690821 @default.
- W7801047 hasConcept C2779341262 @default.
- W7801047 hasConcept C2781236682 @default.
- W7801047 hasConcept C2781253189 @default.
- W7801047 hasConcept C3017875465 @default.
- W7801047 hasConcept C501593827 @default.
- W7801047 hasConcept C86803240 @default.
- W7801047 hasConcept C8891405 @default.
- W7801047 hasConcept C89423630 @default.
- W7801047 hasConceptScore W7801047C136449434 @default.
- W7801047 hasConceptScore W7801047C159654299 @default.
- W7801047 hasConceptScore W7801047C193419808 @default.
- W7801047 hasConceptScore W7801047C203014093 @default.
- W7801047 hasConceptScore W7801047C2776548049 @default.
- W7801047 hasConceptScore W7801047C2778690821 @default.
- W7801047 hasConceptScore W7801047C2779341262 @default.
- W7801047 hasConceptScore W7801047C2781236682 @default.
- W7801047 hasConceptScore W7801047C2781253189 @default.
- W7801047 hasConceptScore W7801047C3017875465 @default.
- W7801047 hasConceptScore W7801047C501593827 @default.
- W7801047 hasConceptScore W7801047C86803240 @default.
- W7801047 hasConceptScore W7801047C8891405 @default.
- W7801047 hasConceptScore W7801047C89423630 @default.
- W7801047 hasIssue "1_Supplement" @default.
- W7801047 hasLocation W78010471 @default.
- W7801047 hasOpenAccess W7801047 @default.
- W7801047 hasPrimaryLocation W78010471 @default.
- W7801047 hasRelatedWork W1545725892 @default.
- W7801047 hasRelatedWork W1571258095 @default.
- W7801047 hasRelatedWork W2031253481 @default.
- W7801047 hasRelatedWork W2045024356 @default.
- W7801047 hasRelatedWork W2355350209 @default.
- W7801047 hasRelatedWork W2478580149 @default.
- W7801047 hasRelatedWork W2951371476 @default.
- W7801047 hasRelatedWork W4307359803 @default.
- W7801047 hasRelatedWork W4381570565 @default.
- W7801047 hasRelatedWork W573847062 @default.
- W7801047 hasVolume "178" @default.
- W7801047 isParatext "false" @default.
- W7801047 isRetracted "false" @default.
- W7801047 magId "7801047" @default.
- W7801047 workType "article" @default.