Matches in SemOpenAlex for { <https://semopenalex.org/work/W78052005> ?p ?o ?g. }
- W78052005 abstract "In our present study we investigated the association between platelet aggregation in patients treated with the most widely used antiplatelet agents (100 and 300-325 mg acetylsalicylic acid (ASA), 75 mg clopidogrel, 500 mg ticlopidine and the combination of 100 mg aspirin and 75 mg clopidogrel), fibrinogen levels and aging. Between 2001 and 2005 we measured in vitro platelet aggregation in 5026 vascular patients according to the method of Born. Platelet aggregation was tested with 5 and 10 microM adenosine-diphosphate, 2 microg/ml collagen and 10 microM epinephrine stimulants. Fibrinogen level was simultaneously measured in a subgroup of 3243 patients. The subjects were divided by age into decades. Platelet aggregation increased significantly with advancing age in the case of 100 and 300-325 mg ASA-treated patients (p<0.001). In aspirin-treated patients also fibrinogen levels increased with aging (p<0.001). There was no association between platelet aggregation or fibrinogen levels and aging either in patients treated with 75 mg clopidogrel or with 500 mg ticlopidine. Thienopyridine-treated patients exhibited significantly lower fibrinogen levels than ASA-treated individuals (p<0.001). Our results suggest that advancing age is associated with elevated platelet aggregability in widely used antiplatelet regimens that might contribute to higher risk of cardiovascular events in the elderly." @default.
- W78052005 created "2016-06-24" @default.
- W78052005 creator A5006055462 @default.
- W78052005 creator A5007667786 @default.
- W78052005 creator A5013214539 @default.
- W78052005 creator A5025142343 @default.
- W78052005 creator A5028627822 @default.
- W78052005 creator A5043415555 @default.
- W78052005 creator A5066423655 @default.
- W78052005 creator A5091277376 @default.
- W78052005 creator A5091417916 @default.
- W78052005 date "2008-01-01" @default.
- W78052005 modified "2023-09-24" @default.
- W78052005 title "Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients" @default.
- W78052005 cites W1515517445 @default.
- W78052005 cites W1963714529 @default.
- W78052005 cites W1964430718 @default.
- W78052005 cites W1981790872 @default.
- W78052005 cites W1983854928 @default.
- W78052005 cites W1989615944 @default.
- W78052005 cites W1997343401 @default.
- W78052005 cites W2007675502 @default.
- W78052005 cites W2011863243 @default.
- W78052005 cites W2013969518 @default.
- W78052005 cites W2017453532 @default.
- W78052005 cites W2019399894 @default.
- W78052005 cites W2058874291 @default.
- W78052005 cites W2084383114 @default.
- W78052005 cites W2085190889 @default.
- W78052005 cites W2098432330 @default.
- W78052005 cites W2123882572 @default.
- W78052005 cites W2128630796 @default.
- W78052005 cites W2152401347 @default.
- W78052005 cites W2152609075 @default.
- W78052005 cites W2161043271 @default.
- W78052005 cites W2165160171 @default.
- W78052005 cites W2169307038 @default.
- W78052005 cites W2227474081 @default.
- W78052005 cites W23524587 @default.
- W78052005 cites W2411963069 @default.
- W78052005 doi "https://doi.org/10.3233/ch-2008-1140" @default.
- W78052005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19126992" @default.
- W78052005 hasPublicationYear "2008" @default.
- W78052005 type Work @default.
- W78052005 sameAs 78052005 @default.
- W78052005 citedByCount "12" @default.
- W78052005 countsByYear W780520052013 @default.
- W78052005 countsByYear W780520052014 @default.
- W78052005 countsByYear W780520052016 @default.
- W78052005 countsByYear W780520052021 @default.
- W78052005 crossrefType "journal-article" @default.
- W78052005 hasAuthorship W78052005A5006055462 @default.
- W78052005 hasAuthorship W78052005A5007667786 @default.
- W78052005 hasAuthorship W78052005A5013214539 @default.
- W78052005 hasAuthorship W78052005A5025142343 @default.
- W78052005 hasAuthorship W78052005A5028627822 @default.
- W78052005 hasAuthorship W78052005A5043415555 @default.
- W78052005 hasAuthorship W78052005A5066423655 @default.
- W78052005 hasAuthorship W78052005A5091277376 @default.
- W78052005 hasAuthorship W78052005A5091417916 @default.
- W78052005 hasConcept C126322002 @default.
- W78052005 hasConcept C2775859304 @default.
- W78052005 hasConcept C2777399203 @default.
- W78052005 hasConcept C2777628954 @default.
- W78052005 hasConcept C2777849778 @default.
- W78052005 hasConcept C2778905298 @default.
- W78052005 hasConcept C2779036427 @default.
- W78052005 hasConcept C2779837110 @default.
- W78052005 hasConcept C2993802102 @default.
- W78052005 hasConcept C3018697912 @default.
- W78052005 hasConcept C71924100 @default.
- W78052005 hasConcept C89560881 @default.
- W78052005 hasConcept C98274493 @default.
- W78052005 hasConceptScore W78052005C126322002 @default.
- W78052005 hasConceptScore W78052005C2775859304 @default.
- W78052005 hasConceptScore W78052005C2777399203 @default.
- W78052005 hasConceptScore W78052005C2777628954 @default.
- W78052005 hasConceptScore W78052005C2777849778 @default.
- W78052005 hasConceptScore W78052005C2778905298 @default.
- W78052005 hasConceptScore W78052005C2779036427 @default.
- W78052005 hasConceptScore W78052005C2779837110 @default.
- W78052005 hasConceptScore W78052005C2993802102 @default.
- W78052005 hasConceptScore W78052005C3018697912 @default.
- W78052005 hasConceptScore W78052005C71924100 @default.
- W78052005 hasConceptScore W78052005C89560881 @default.
- W78052005 hasConceptScore W78052005C98274493 @default.
- W78052005 hasLocation W780520051 @default.
- W78052005 hasLocation W780520052 @default.
- W78052005 hasOpenAccess W78052005 @default.
- W78052005 hasPrimaryLocation W780520051 @default.
- W78052005 hasRelatedWork W2074762647 @default.
- W78052005 hasRelatedWork W2077119415 @default.
- W78052005 hasRelatedWork W2079293886 @default.
- W78052005 hasRelatedWork W2087103870 @default.
- W78052005 hasRelatedWork W2152401347 @default.
- W78052005 hasRelatedWork W2368367966 @default.
- W78052005 hasRelatedWork W2575946902 @default.
- W78052005 hasRelatedWork W2739317526 @default.
- W78052005 hasRelatedWork W3149477379 @default.
- W78052005 hasRelatedWork W78052005 @default.