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• W780651610 abstract "Inter-individual differences in strength are not fully explained by muscle size, suggestingthat muscle specific tension [force per unit physiological cross-sectional area (PCSA)]varies between untrained individuals. Furthermore, many reports demonstrate greater gainsin muscle strength than size following resistance training, thus indicating an increase inspecific tension. Moreover, there is considerable variation in the response to training thatmay have a genetic origin. The aims of the work described in this thesis were i) to examinethe degree of variability in muscle specific tension; ii) to investigate whether specifictension changed following resistance training; iii) to quantify the variability in the responseof human muscle to resistance training; iv) to identify gene variants that may be associatedwith the variable training responses. In a group of untrained young men and before andafter 9 weeks of resistance training, the quadriceps femoris (QF) muscle specific tensionwas calculated from the maximum isometric voluntary contraction (MVC) torque, takinginto account the contribution of voluntary activation, antagonist muscle co-activation,moment arm length, QF volume, muscle fascicle length and pennation angle. Correctingfor these factors made little difference to the between subjects variance of MVC torque,thus demonstrating that muscle specific tension varies considerably between individuals.Resistance training increased QF muscle force much more than PCSA, indicating that mostof the increase in force was a result of increased specific tension. This increase was notassociated with a change in myosin heavy chain expression and was not accompanied byan increase in single fibre specific tension, or an increase in power per unit muscle volumemeasured during isokinetic cycling. The results are consistent with an increase in lateralforce transmission in the muscle. Substantial variation in the training responses wasobserved and the final part of this thesis is concerned with linking this variation withspecific gene variants." @default.
• W780651610 created "2016-06-24" @default.
• W780651610 creator A5014700416 @default.
• W780651610 date "2010-01-01" @default.
• W780651610 modified "2023-09-27" @default.
• W780651610 title "The inter-individual variability in human muscle strength and in the response to resistance training" @default.
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