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- W780730996 abstract "OBJECTIVE: Describe the clinical features of children with cerebral palsy ( CP) treated with intrathecal lioresal ( ITB) who died, in a cohort of 117 patients followed for up to 13 yearsBACKGROUND: Mortality is higher in children with CP. Motor impairment from spasticity and weakness increase the risk. ITB is an effective and approved treatment to treat severe spasticity and improve mobility. Not much is known about mortality in CP children with ITB.DESIGN/METHODS: Retrospective chart review of CP children treated with ITB. Age at death, duration of ITB treatment, time after pump placement, distribution of spasticity, seizure, pulmonary, gastrointestinal and other co-morbidities, and medications analyzed.RESULTS: Twelve patients died over 13 years. Ages ranged from 5 to 17 years, eight were over 10 years. Duration of ITB treatment was from 10 months to 9 years; in 5 duration less than 2 years. Quadriplegic CP in 10; epilepsy in 9, four anti epileptic drugs ( AED) in 3 patients, 3 AED in 2 add in 2 and none in 3. Choreathetosis in 1, panhypopituitarism in 2, gastroesophageal reflux and aspiration in 2. Cause of death was respiratory failure in hospital in 3 and other 9 children died at home in sleep No post mortem exams were performedCONCLUSIONS: 12 out 117 children treated with ITB died over 13 years . Quadriparesis, epilepsy increased risk for death and death rate is not different from CP children not treated with ITB. The deaths were not related to the operative procedure or dose adjustments in ITB therapy.Supported by: None Disclosure: Dr. Vedanarayanan has nothing to disclose. Dr. Vedanarayanan has nothing to disclose. Dr. Parker has nothing to disclose. Dr. White has nothing to disclose. Dr. Davis has nothing to disclose." @default.
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- W780730996 date "2015-04-06" @default.
- W780730996 modified "2023-09-23" @default.
- W780730996 title "Mortality in Children with Cerebral Palsy treated with Intrathecal Baclofen Pump (P6.251)" @default.
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