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• W781006001 abstract "OBJECTIVE: To determine if the use of intra-operative microelectrode recording (MER) influences the final location of lead implant in Parkinson’s disease (PD) patients undergoing deep brain stimulation (DBS) and to assess the incidence of associated complications.BACKGROUND: The usefulness of intraoperative MER in DBS for PD patients is debated by some DBS implanting centers, suggesting it increases surgical complications and offers no additional benefit.METHODS: We conducted a retrospective chart review of all PD patients who underwent DBS with MER at the University of Texas Health Science Center in Houston from June 1st 2009 to October 1st 2013. A total of 88 lead implants on 45 patients were reviewed, 62 leads in sub thalamic nucleus (STN) and 26 in globus pallidus interna (GPi). Initial coordinates, as determined with a pre-operative MRI, and final coordinates of implant after intra-operative MER were compared. To assess hemorrhagic and infectious complications, post-operative CT scan of the head and outpatient follow-up notes for a period of 1 year from the date of surgery were reviewed.RESULTS: The mean age at implantation was 64 years (range 40-84). The average duration from diagnosis to surgery was 10 years (range 2-20). A statistically significant difference between the initial and final coordinates was observed only in the superior-inferior plane in both STN (p=0.004) and GPi (p=0.0005) implants, with a respective mean difference of 0.29 mm and 0.63 mm inferiorly. No patient had an infectious complication. One patient (2.2[percnt]) had subdural blood layering and 6 (13.3[percnt]) had minimal intra-ventricular bleeding on post-operative CT, of which only 1 (2.2[percnt]) had transient seizures. None of them had hypertension or intra-parenchymal hemorrhage. None of the patients required a revision for lack of benefits or uncontrollable side effects.CONCLUSIONS: Intra-operative MER significantly modifies final lead placement and does not seem to increase surgical complications. Disclosure: Dr. Reddy has nothing to disclose. Dr. Fenoy has nothing to disclose. Dr. Furr-Stimming has nothing to disclose. Dr. Ondo has received personal compensation for activities with Teva, Ipsen, UCB, Merz, and Lundbeck as a speaker and consultant. Dr. Schiess has nothing to disclose. Dr. Mehanna has nothing to disclose." @default.
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• W781006001 date "2015-04-06" @default.
• W781006001 modified "2023-09-28" @default.
• W781006001 title "Does the Use of Intraoperative Microelectrode Recording Influence the Final Location of Lead Implant in Deep Brain Stimulation in Parkinson’s Disease Patients? (P1.166)" @default.
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