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- W78138879 startingPage "63.4" @default.
- W78138879 abstract "Abstract Follicular helper T cells (TFH) are a unique subset of CD4+ helper T cells that are critical effectors of thymus-dependent humoral immune responses, yet much about their development in vivo remains unclear and controversial. The requirements for different antigen presenting cell subsets in TFH formation are not yet fully understood. By transiently ablating or restricting MHCII antigen presentation to CD11chi dendritic cells (DCs), we show that cognate, MHCII dependent interactions with DCs are both necessary and sufficient for the formation of CXCR5+, ICOS+ TFH cells that express the key transcription factor Bcl6, which governs their differentiation. However, TFH cells that do not undergo TCR-MHCII-dependent interactions with B cells lack a small subset of GL-7+ PD1hi cells found in the germinal center (GC) and GCs fail to form. These TFH exhibit a significant reduction in their ability to produce IL-21 when compared to TFH cells generated in the presence of cognate B cell interactions. Consistent with these data, in vitro priming of naïve T cells by B cells, but not DCs, induces optimal IL-21 production, which, in turn, induces a GC B cell transcriptional profile. Thus, this study supports a multi-step model for priming effector TFH in which DCs activate CD4+ T cell towards a poised intermediate which can then interact with responding B cells to sustain the GC status of both cell types." @default.
- W78138879 created "2016-06-24" @default.
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- W78138879 date "2011-04-01" @default.
- W78138879 modified "2023-10-14" @default.
- W78138879 title "T follicular helper cells require cognate B cell interactions for acquisition of full effector function (63.4)" @default.
- W78138879 doi "https://doi.org/10.4049/jimmunol.186.supp.63.4" @default.
- W78138879 hasPublicationYear "2011" @default.
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