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• W78187851 abstract "Back to table of contents Previous article Next article No AccessComorbid Tourette's disorder and bipolar disorder: an etiologic perspectivePublished Online:1 Apr 2006https://doi.org/10.1176/ajp.152.11.1646AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: Using an epidemiologic approach, the authors attempt to elucidate relationships between Tourette's disorder and bipolar disorder. METHOD: Of 205 patients with Tourette's disorder in the North Dakota Longitudinal Tourette Syndrome Surveillance Project, 15 had comorbid bipolar disorder. A subset of the patients with Tourette's disorder had been included in earlier population-based prevalence studies of Tourette's disorder in children, adolescents, and adults. Minimal risk ratios were calculated for the patients with Tourette's disorder plus bipolar disorder by age group (children/adolescents and adults). This information was used to estimate genetic risk indicators for comorbid Tourette's disorder and bipolar disorder. RESULTS: The estimated risk of developing bipolar disorder among the study group of children, adolescents, and adults with Tourette's disorder was more than four times higher than the level expected by chance, but this finding did not reach statistical significance. It was indicative of trends, however. CONCLUSIONS: Comorbidity between Tourette's disorder and bipolar disorder does not appear to be due to chance co-occurrence of the two disorders. Although a genetic mechanism may play a causal role, in the absence of family studies an explanatory model involving the concept of canalization of basal-ganglia-mediated dysfunctions is offered. In such a construct, Tourette's disorder would be a likely accompaniment to other conditions, including bipolar disorder, whose pathogenic determinants might channel through neural pathways involving the basal ganglia. The presence of significant developmental disabilities may further enhance factors culminating in comorbid Tourette's disorder and bipolar disorder. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byDynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Psychiatric Disorders2 June 2022 | Frontiers in Neuroscience, Vol. 16Pediatric Clinics of North America, Vol. 62, No. 3Comorbidity14 November 2014Psychiatric Clinics of North America, Vol. 37, No. 3Trends in Psychiatry and Psychotherapy, Vol. 36, No. 3Clinical Psychopharmacology and Neuroscience, Vol. 12, No. 3Movement Disorders: Tics and Tourette's Disorder30 March 2012The Kaohsiung Journal of Medical Sciences, Vol. 25, No. 11Journal of Psychosomatic Research, Vol. 67, No. 6Psychiatry Research, Vol. 170, No. 1Psychiatric comorbidity in a girl with Saethre–Chotzen syndromePsychiatric Genetics, Vol. 18, No. 5Journal of Child and Family Studies, Vol. 17, No. 4European Child & Adolescent Psychiatry, Vol. 16, No. S1Chronic tics and Tourette syndrome in patients with obsessive–compulsive disorderJournal of Psychiatric Research, Vol. 40, No. 6Journal of Psychosomatic Research, Vol. 61, No. 3NeuroRX, Vol. 3, No. 2Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 45, No. 11Moving Target: The Developing Social Brain and PsychopathologyPsychiatric Annals, Vol. 35, No. 10The American Journal of Human Genetics, Vol. 75, No. 4Psychiatry and Clinical Neurosciences, Vol. 58, No. 4, Vol. 20046181Neurologic Clinics, Vol. 19, No. 3American Journal of Medical Genetics, Vol. 96, No. 1Current Psychiatry Reports, Vol. 2, No. 2Biological Psychiatry, Vol. 48, No. 10Journal of Intellectual Disability Research, Vol. 44, No. 1Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 39, No. 5Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 39, No. 5The Journal of Nervous and Mental Disease, Vol. 188, No. 9Comorbidity in bipolar affective disorderBiological Psychiatry, Vol. 43, No. 5The Journal of Nervous &amp Mental Disease, Vol. 186, No. 4Current Opinion in Neurology, Vol. 11, No. 4The Construct of Canalization and Tourette Syndrome4 December 2016 | Perceptual and Motor Skills, Vol. 84, No. 1Neurologic Clinics, Vol. 15, No. 2Neurologic Clinics, Vol. 15, No. 2The Journal of Psychology, Vol. 131, No. 6Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 35, No. 5Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 35, No. 12Pediatric Neurology Briefs, Vol. 9, No. 12 Volume 152Issue 11 November 1995Pages 1646-1651 Metrics PDF download History Published online 1 April 2006 Published in print 1 November 1995" @default.
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