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- W7825645 abstract "Abstract Follicular dendritic cells (FDCs) are well known to retain the immune complexes that drive antibody affinity maturation. Here, we present evidence that FDC-bound antigens are also persistently sampled by bone marrow-derived DCs for presentation to CD8 T cells. These results are based upon our previous observation that ovalbumin (OVA) expressed in transmembrane form by the placenta is hematogenously released during pregnancy to accumulate on maternal FDCs throughout all secondary lymphoid organs. We now show that OVA loading onto FDCs is complement-dependent and that bound OVA is retained for several weeks after delivery. Strikingly, antigen retention correlated with a prolonged postpartum phase of OVA presentation to CD8 T cells that could be abrogated by the pharmacological ablation of FDC networks. Furthermore, bone marrow chimera experiments demonstrated that FDC-bound OVA could be acquired de novo by DCs arising in the postpartum period. The presentation of placental OVA acquired from FDC-associated depots was highly tolerogenic as it induced T cell deletion even in the presence of exogenous adjuvants. These results suggest an unanticipated level of control over peripheral tolerance induction potentially relevant to the pathogenesis of systemic lupus erythematosus, an autoimmune disease characterized by impaired tolerance to apoptosis-associated antigens opsonized by the complement system. Supported by NIH grant RO1-AI062980." @default.
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- W7825645 date "2010-04-01" @default.
- W7825645 modified "2023-10-16" @default.
- W7825645 title "Regulation of CD8 T cell responses by follicular dendritic cell-bound antigen (98.17)" @default.
- W7825645 doi "https://doi.org/10.4049/jimmunol.184.supp.98.17" @default.
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