Matches in SemOpenAlex for { <https://semopenalex.org/work/W78295568> ?p ?o ?g. }
- W78295568 abstract "The folate receptor (FR) type β is a promising target for therapeutic intervention in acute myelogenous leukemia (AML) owing particularly to its selective up-regulation in the leukemic cells by all-trans retinoic acid (ATRA). Here we show, using KG-1 and MV4- 11 AML cells and recombinant 293 cells, that the histone deacetylase (HDAC) inhibitors Trichostatin A (TSA), valproic acid (VPA) and FK228 potentiated ATRA induction of FR-β gene transcription and FR-β mRNA/protein expression. ATRA and/or TSA did not induce de novo FR synthesis in any of a variety of FR-negative cell lines tested. TSA did not alter the effect of ATRA on the expression of retinoic acid receptors (RARs) α, β or γ. Chromatin immunoprecipitation (ChIP) assays indicate that HDAC inhibitors act on the FR-β gene by enhancing RAR-associated histone acetylation to increase the association of Sp1 with the basal FR-β promoter. Under these conditions, the expression level of Sp1 is unaltered. A decreased availability of putative repressor Ap-1 proteins may also indirectly contribute to the effect of HDAC inhibitors. Finally, FR-β selectively mediated cell growth inhibition by (6S) dideaza tetrahydrofolate in a manner that was greatly potentiated in AML cells by ATRA and HDAC inhibition. Therefore, the combination of ATRA and innocuous HDAC inhibitors may be expected to facilitate selective FR-β-targeted therapies in AML." @default.
- W78295568 created "2016-06-24" @default.
- W78295568 creator A5014870101 @default.
- W78295568 date "2005-01-01" @default.
- W78295568 modified "2023-09-23" @default.
- W78295568 title "Modulation of Folate Receptor Beta for Drug Targeting in Acute Myelogenous Leukemia" @default.
- W78295568 cites W109931055 @default.
- W78295568 cites W112958514 @default.
- W78295568 cites W1486948598 @default.
- W78295568 cites W1488530423 @default.
- W78295568 cites W1488798457 @default.
- W78295568 cites W1489522726 @default.
- W78295568 cites W1500793474 @default.
- W78295568 cites W1504640316 @default.
- W78295568 cites W1515543767 @default.
- W78295568 cites W1524027952 @default.
- W78295568 cites W1536225466 @default.
- W78295568 cites W1543288352 @default.
- W78295568 cites W1544547269 @default.
- W78295568 cites W1550565578 @default.
- W78295568 cites W1550970290 @default.
- W78295568 cites W1551102474 @default.
- W78295568 cites W1554600230 @default.
- W78295568 cites W1560482245 @default.
- W78295568 cites W1563624749 @default.
- W78295568 cites W1587947784 @default.
- W78295568 cites W1594606204 @default.
- W78295568 cites W1597619535 @default.
- W78295568 cites W1598192021 @default.
- W78295568 cites W1603742465 @default.
- W78295568 cites W1606327354 @default.
- W78295568 cites W1647609745 @default.
- W78295568 cites W165015714 @default.
- W78295568 cites W1827980340 @default.
- W78295568 cites W1849493927 @default.
- W78295568 cites W1862410697 @default.
- W78295568 cites W188006079 @default.
- W78295568 cites W1908380983 @default.
- W78295568 cites W191075349 @default.
- W78295568 cites W1919210158 @default.
- W78295568 cites W1919339218 @default.
- W78295568 cites W1927684145 @default.
- W78295568 cites W1960032085 @default.
- W78295568 cites W1969839676 @default.
- W78295568 cites W1969855337 @default.
- W78295568 cites W1971804824 @default.
- W78295568 cites W1972375217 @default.
- W78295568 cites W1972849029 @default.
- W78295568 cites W1973713328 @default.
- W78295568 cites W1973908838 @default.
- W78295568 cites W1975263958 @default.
- W78295568 cites W1975556125 @default.
- W78295568 cites W1976155578 @default.
- W78295568 cites W1979745458 @default.
- W78295568 cites W1979832500 @default.
- W78295568 cites W1980742800 @default.
- W78295568 cites W1981022538 @default.
- W78295568 cites W1981718275 @default.
- W78295568 cites W1982342754 @default.
- W78295568 cites W1982396632 @default.
- W78295568 cites W1982650996 @default.
- W78295568 cites W1983094204 @default.
- W78295568 cites W1983266647 @default.
- W78295568 cites W1984587147 @default.
- W78295568 cites W1985684133 @default.
- W78295568 cites W1986020552 @default.
- W78295568 cites W1987040411 @default.
- W78295568 cites W1988272691 @default.
- W78295568 cites W1988430662 @default.
- W78295568 cites W1990939350 @default.
- W78295568 cites W1992593557 @default.
- W78295568 cites W1993019497 @default.
- W78295568 cites W1993243592 @default.
- W78295568 cites W1995754186 @default.
- W78295568 cites W1995902306 @default.
- W78295568 cites W1995967787 @default.
- W78295568 cites W1995980440 @default.
- W78295568 cites W1997473658 @default.
- W78295568 cites W1998128870 @default.
- W78295568 cites W1998290168 @default.
- W78295568 cites W1998904806 @default.
- W78295568 cites W2004406962 @default.
- W78295568 cites W2008977792 @default.
- W78295568 cites W2009193838 @default.
- W78295568 cites W2009886857 @default.
- W78295568 cites W2010680800 @default.
- W78295568 cites W2013315155 @default.
- W78295568 cites W2013919931 @default.
- W78295568 cites W2014760566 @default.
- W78295568 cites W2015589904 @default.
- W78295568 cites W2019296629 @default.
- W78295568 cites W2021764224 @default.
- W78295568 cites W2023563721 @default.
- W78295568 cites W2025631499 @default.
- W78295568 cites W2026237709 @default.
- W78295568 cites W2028776386 @default.
- W78295568 cites W2029903254 @default.
- W78295568 cites W2031539004 @default.
- W78295568 cites W2031671750 @default.
- W78295568 cites W2037260804 @default.