Matches in SemOpenAlex for { <https://semopenalex.org/work/W78316076> ?p ?o ?g. }
- W78316076 abstract "Thiomarinol is a novel hybrid antibiotic produced by (Pseudoalteromonas) (rava) sp. nov. SANK 73390. It is structurally similar to a clinically significant antibiotic mupirocin, but includes an additional pyrrothine moiety joined to the mupirocin-like marinolic acid via an amide bond. Thiomarinol has been shown to be more potent against a wider range of microorganisms. This potency was hypothesised to be due to either an increase in inhibition of its target enzyme, isoleucyl-tRNA synthetase (IleS) or an increase in antibiotic uptake and/or inefficient efflux by bacterial cells or a combination of both. This thesis describes experiments that investigate the basis for this increase in potency." @default.
- W78316076 created "2016-06-24" @default.
- W78316076 creator A5056570479 @default.
- W78316076 date "2015-07-01" @default.
- W78316076 modified "2023-09-28" @default.
- W78316076 title "Investigating the antibacterial potency and spectrum of activity of the antibiotic thiomarinol" @default.
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