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- W78348002 abstract "The ability, either innate or acquired, to produce β-lactamases, enzymes capable of hydrolyzing the endocyclic peptide bond in β-lactam antibiotics, would appear to be a primary contributor to the ever-increasing incidences of resistance to this class of antibiotics. To date, four distinct classes, A, B, C, and D, of β-lactamases have been identified. Of these, enzymes in classes A, C, and D utilize a serine residue as a nucleophile in their catalytic mechanism while class B members are Zn+2-dependent for their function. Efforts have been and still continue to be made toward the development of potent inhibitors of these enzymes as a means to ensure the efficacy of β-lactam antibiotics in clinical medicine. This chapter concerns procedures for the evaluation of the catalytic activity of β-lactamases as a means to screen compounds for their inhibitory potency." @default.
- W78348002 created "2016-06-24" @default.
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- W78348002 date "2008-01-01" @default.
- W78348002 modified "2023-09-27" @default.
- W78348002 title "Assays for Β-Lactamase Activity and Inhibition" @default.
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- W78348002 doi "https://doi.org/10.1007/978-1-59745-246-5_19" @default.
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