Matches in SemOpenAlex for { <https://semopenalex.org/work/W783847802> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W783847802 abstract "To investigate the relationship between chromosome aberrations induced by radiation and chromatin folding, we reconstructed three dimensional structure of chromosome 3 and measured the physical distances between different regions of the chromosome. Previously, we have investigated the location of breaks involved in inter- and intrachromosomal type exchange events in human chromosome 3, using the multicolor banding in situ hybridization (mBAND) technique. In human epithelial cells exposed to both low- and high-LET radiations in vitro, we reported that intra-chromosome exchanges occurred preferentially between a break in the 3p21 and one in the 3q11 regions, and the breaks involving in inter-chromosome exchanges occurred in two regions towards the telomeres of the chromosome. Exchanges were also observed between a break in 3p21 and one in 3q26, but few exchanges were observed between breaks in 3q11 and 3q26, even though the two regions are located on the same arm of the chromosome. In this study, human epithelial cells were fixed at G1 phase and the interphase cells were hybridized using the XCyte3 mBAND kit from MetaSystems. The z-section images of chromosome 3 were captured with a Leica and an LSM 510 Meta laser scanning confocal microscopes. A total of 100 chromosomes were analyzed. The reconstruction of three dimensional structure of interphase chromosome 3 with six different colored regions was achieved using the Imaris software. The relative distance between different regions was measured as well. We further analyzed fragile sites on the chromosome that have been identified in various types of cancers. The data showed that, in majority of the cells, the regions containing 3p21 and 3q11 are colocalized in the center of the chromosome, whereas, the regions towards the telomeres of the chromosome are either physically wrapping outside the chromosome center or with arms sticking out. Our results demonstrated that the distribution of breaks involved in radiation-induced inter and intra-chromosome aberrations depends upon both the location of fragile sites and the folding of chromatins." @default.
- W783847802 created "2016-06-24" @default.
- W783847802 creator A5003597482 @default.
- W783847802 creator A5025612495 @default.
- W783847802 creator A5030677771 @default.
- W783847802 creator A5042760638 @default.
- W783847802 creator A5059239993 @default.
- W783847802 creator A5082117229 @default.
- W783847802 date "2011-01-01" @default.
- W783847802 modified "2023-09-27" @default.
- W783847802 title "The Correlation of Interphase Chromatin Structure with the Radiation-Induced Inter- and Intrachromosome Exchange Hotspots" @default.
- W783847802 hasPublicationYear "2011" @default.
- W783847802 type Work @default.
- W783847802 sameAs 783847802 @default.
- W783847802 citedByCount "0" @default.
- W783847802 crossrefType "journal-article" @default.
- W783847802 hasAuthorship W783847802A5003597482 @default.
- W783847802 hasAuthorship W783847802A5025612495 @default.
- W783847802 hasAuthorship W783847802A5030677771 @default.
- W783847802 hasAuthorship W783847802A5042760638 @default.
- W783847802 hasAuthorship W783847802A5059239993 @default.
- W783847802 hasAuthorship W783847802A5082117229 @default.
- W783847802 hasConcept C104317684 @default.
- W783847802 hasConcept C163588314 @default.
- W783847802 hasConcept C177336024 @default.
- W783847802 hasConcept C182483264 @default.
- W783847802 hasConcept C29452124 @default.
- W783847802 hasConcept C30481170 @default.
- W783847802 hasConcept C47924181 @default.
- W783847802 hasConcept C54355233 @default.
- W783847802 hasConcept C552990157 @default.
- W783847802 hasConcept C83640560 @default.
- W783847802 hasConcept C86803240 @default.
- W783847802 hasConceptScore W783847802C104317684 @default.
- W783847802 hasConceptScore W783847802C163588314 @default.
- W783847802 hasConceptScore W783847802C177336024 @default.
- W783847802 hasConceptScore W783847802C182483264 @default.
- W783847802 hasConceptScore W783847802C29452124 @default.
- W783847802 hasConceptScore W783847802C30481170 @default.
- W783847802 hasConceptScore W783847802C47924181 @default.
- W783847802 hasConceptScore W783847802C54355233 @default.
- W783847802 hasConceptScore W783847802C552990157 @default.
- W783847802 hasConceptScore W783847802C83640560 @default.
- W783847802 hasConceptScore W783847802C86803240 @default.
- W783847802 hasLocation W7838478021 @default.
- W783847802 hasOpenAccess W783847802 @default.
- W783847802 hasPrimaryLocation W7838478021 @default.
- W783847802 hasRelatedWork W123135237 @default.
- W783847802 hasRelatedWork W1543433242 @default.
- W783847802 hasRelatedWork W1637587117 @default.
- W783847802 hasRelatedWork W1979563995 @default.
- W783847802 hasRelatedWork W1995169790 @default.
- W783847802 hasRelatedWork W2012163074 @default.
- W783847802 hasRelatedWork W2064873018 @default.
- W783847802 hasRelatedWork W2091356429 @default.
- W783847802 hasRelatedWork W2094271869 @default.
- W783847802 hasRelatedWork W2096894672 @default.
- W783847802 hasRelatedWork W2099189440 @default.
- W783847802 hasRelatedWork W2160663120 @default.
- W783847802 hasRelatedWork W2169314117 @default.
- W783847802 hasRelatedWork W2194876025 @default.
- W783847802 hasRelatedWork W2321432223 @default.
- W783847802 hasRelatedWork W2896582965 @default.
- W783847802 hasRelatedWork W386138380 @default.
- W783847802 hasRelatedWork W640509793 @default.
- W783847802 hasRelatedWork W840025385 @default.
- W783847802 hasRelatedWork W931734827 @default.
- W783847802 isParatext "false" @default.
- W783847802 isRetracted "false" @default.
- W783847802 magId "783847802" @default.
- W783847802 workType "article" @default.