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- W78473685 abstract "Schwann cell behaviour can be investigated in experimental nerve grafts where Schwann cells in the grafted nerve segments survive and myelinate axons regenerating from the proximal stump of the host nerve. By selecting host and donor nerves, it is possible to create different combinations of axons and Schwann cells from normal and abnormal nerves. Thus, Schwann cells from human patients and allogenic mice have been transplanted into nerves of immunesuppressed mice and studied by quantitative ultrastructural and radioautographic techniques. The results of these experimental nerve grafts indicate that: (a) there is a primary failure of Schwann cells to form and sustain myelin in Trembler and quaking mice, (b) the abnormal persistence of Schwann cell proliferation which is found in Trembler nerves also occurs when Trembler Schwann cells are transplanted into normal nerves, (c) normal myelination influences the calibre of axons, (d) transplanted human Schwann cells can myelinate mouse axons, (e) myelination is deficient in transplants from the sural nerve of a patient with Charcot-Marie-Tooth neuropathy." @default.
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- W78473685 date "1978-01-01" @default.
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- W78473685 title "HUMAN AND ANIMAL NEUROPATHIES STUDIED IN EXPERIMENTAL NERVE TRANSPLANTS" @default.
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- W78473685 doi "https://doi.org/10.1016/b978-0-444-80079-4.50007-7" @default.
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