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- W785143750 abstract "Renin-angiotensin system (RAS) plays an essential role in cardiovascular homeostasis. The peptide hormone angiotensin II (Ang II), generated by angiotensin converting enzyme (ACE), mainly regulates cardiovascular system via its receptors. More recently, we have reported that Ang-(1–7) stimulates ANP secretion via Mas receptor. However, Ang-(1–9), converted from Ang I by ACE 2, is still unknown. The aim of the present study is to determine whether Ang-(1–9) stimulates ANP secretion using isolated perfused beating atria and to find out its signaling pathway. Ang-(1–9) augmented ANP secretion and concentration in a dose-dependent manner. Ang-(1–9)-induced ANP secretion (about 60% increase by 3 uM) was attenuated by the pretreatment with Ang II type 2 receptor (AT2R) antagonist but not by AT1R or Mas receptor antagonist. In addition, pretreatment with inhibitors of phosphatidylinositol 3 kinase(PI3K), protein kinase B (Akt), endothelial nitric oxide synthase (eNOS) or guanylyl cyclase (GC), blocked the attenuation of ANP secretion by Ang-(1–9). However, Ang-(1–9) did not influence atrial contractility and ECF translocation. These results suggest that Ang-(1–9) stimulates ANP secretion via AT2R, PI3K, Akt, eNOs, GC pathway. We try to do further study to find out the signaling mechanism involved these responses. Supported by the National Research Foundation (2012–0009322 )" @default.
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- W785143750 date "2013-04-01" @default.
- W785143750 modified "2023-09-27" @default.
- W785143750 title "Stimulation of ANP secretion by Angiotensin‐(1–9) via Angiotensin Type 2 Receptor" @default.
- W785143750 doi "https://doi.org/10.1096/fasebj.27.1_supplement.lb688" @default.
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