Matches in SemOpenAlex for { <https://semopenalex.org/work/W785565175> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W785565175 abstract "Travelling wave ion mobility spectrometry (TWIMS) in combination with ultra-high performance liquid chromatography (UHPLC) and mass spectrometry (MS) has been applied successfully for the untargeted, global metabolic profiling of biofluids such as mouse plasma and saliva. Methods based on UHPLC-MS alone and in combination with ion mobility spectrometry (UHPLC-IM-MS) have been developed and validated for the untargeted metabolite profiling of saliva, obtained non-invasively by passive drool. Three separate metabolic profiling studies have been carried out in conjunction with bioinformatics strategies to identify potential metabolomic biomarker ions that are associated with efficacy of rice bran in colorectal cancer, physiological stress and that have the potential for the diagnosis of asthma. The advantages offered by the utility of ion mobility in UHPLC-MS based metabolic profiling studies, including the increased analytical space, mass spectral clean-up of contaminants such as PEG post-UHPLC-IM-MS analysis, enhancement of the selectivity of targeted metabolites as well as the potential for the identification of metabolites by comparison of ion mobility drift times have been highlighted.Ten potential metabolic biomarker ions of asthma have been identified from the moderate asthmatics from untargeted metabolite profiling of saliva by UHPLC-MS. A predictive model based on partial least squares discriminant analysis (PLS-DA) has been constructed using these ten discriminant ions, which demonstrates good predictive capability for moderate asthmatics and controls.Potential metabolic biomarker ions of physiological stress have been identified through untargeted metabolite profiling analysis of saliva samples collected before and after exercise by UHPLC-IM-MS. Valerolactam has been identified as a potential biomarker of physiological stress from saliva by comparison of retention time, ion mobility drift time and MS/MS spectra with a standard of δ-valerolactam." @default.
- W785565175 created "2016-06-24" @default.
- W785565175 creator A5089230879 @default.
- W785565175 date "2014-01-01" @default.
- W785565175 modified "2023-09-27" @default.
- W785565175 title "Analytical methods based on ion mobility and mass spectrometry for metabolomics" @default.
- W785565175 hasPublicationYear "2014" @default.
- W785565175 type Work @default.
- W785565175 sameAs 785565175 @default.
- W785565175 citedByCount "0" @default.
- W785565175 crossrefType "dissertation" @default.
- W785565175 hasAuthorship W785565175A5089230879 @default.
- W785565175 hasConcept C104317684 @default.
- W785565175 hasConcept C124535831 @default.
- W785565175 hasConcept C135870905 @default.
- W785565175 hasConcept C15213710 @default.
- W785565175 hasConcept C162356407 @default.
- W785565175 hasConcept C185592680 @default.
- W785565175 hasConcept C21565614 @default.
- W785565175 hasConcept C2777477808 @default.
- W785565175 hasConcept C2781197716 @default.
- W785565175 hasConcept C2994400308 @default.
- W785565175 hasConcept C43617362 @default.
- W785565175 hasConcept C46111723 @default.
- W785565175 hasConcept C504460877 @default.
- W785565175 hasConcept C55493867 @default.
- W785565175 hasConceptScore W785565175C104317684 @default.
- W785565175 hasConceptScore W785565175C124535831 @default.
- W785565175 hasConceptScore W785565175C135870905 @default.
- W785565175 hasConceptScore W785565175C15213710 @default.
- W785565175 hasConceptScore W785565175C162356407 @default.
- W785565175 hasConceptScore W785565175C185592680 @default.
- W785565175 hasConceptScore W785565175C21565614 @default.
- W785565175 hasConceptScore W785565175C2777477808 @default.
- W785565175 hasConceptScore W785565175C2781197716 @default.
- W785565175 hasConceptScore W785565175C2994400308 @default.
- W785565175 hasConceptScore W785565175C43617362 @default.
- W785565175 hasConceptScore W785565175C46111723 @default.
- W785565175 hasConceptScore W785565175C504460877 @default.
- W785565175 hasConceptScore W785565175C55493867 @default.
- W785565175 hasLocation W7855651751 @default.
- W785565175 hasOpenAccess W785565175 @default.
- W785565175 hasPrimaryLocation W7855651751 @default.
- W785565175 hasRelatedWork W1990031596 @default.
- W785565175 hasRelatedWork W2005441092 @default.
- W785565175 hasRelatedWork W2013878652 @default.
- W785565175 hasRelatedWork W2030257759 @default.
- W785565175 hasRelatedWork W2120171195 @default.
- W785565175 hasRelatedWork W2149529372 @default.
- W785565175 hasRelatedWork W2226268614 @default.
- W785565175 hasRelatedWork W2327371542 @default.
- W785565175 hasRelatedWork W2353526782 @default.
- W785565175 hasRelatedWork W2367021717 @default.
- W785565175 hasRelatedWork W2416418591 @default.
- W785565175 hasRelatedWork W2468200651 @default.
- W785565175 hasRelatedWork W2797100077 @default.
- W785565175 hasRelatedWork W2914550005 @default.
- W785565175 hasRelatedWork W2940700025 @default.
- W785565175 hasRelatedWork W3012110728 @default.
- W785565175 hasRelatedWork W3037589752 @default.
- W785565175 hasRelatedWork W3080695205 @default.
- W785565175 hasRelatedWork W3201694374 @default.
- W785565175 hasRelatedWork W3209702584 @default.
- W785565175 isParatext "false" @default.
- W785565175 isRetracted "false" @default.
- W785565175 magId "785565175" @default.
- W785565175 workType "dissertation" @default.