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- W785937037 abstract "To provide a quantitative assessment of the association between type 2 diabetes mellitus (T2DM) and the risk of colorectal cancer (CRC).Systematic review was conducted thorough MEDLINE, EMBASE, Cochrane Library, and ISI Web of knowledge databases till 31(st) January 2014. This meta-analysis included the cohort studies that illustrated relative risk (RR) or odds ratio estimates with 95%CI for the predictive risk of CRC by T2DM. Summary relative risks with 95%CI were analyzed by using an effects summary ratio model. Heterogeneity among studies was assessed by the Cochran's Q and I (2) statistics.The meta analysis of 8 finally selected studies showed a positive correlation of T2DM with the risk of CRC as depicted by effects summary RR of 1.21 (95%CI: 1.02-1.42). Diabetic women showed greater risk of developing CRC as their effect summary RR of 1.22 (95%CI: 1.01-49) with significant overall Z test at 5% level of significance was higher than the effect summary RR of 1.17 (95%CI: 1.00-1.37) of men showing insignificant Z test. The effect summary RR of 1.19 with 95%CI of 1.07-1.33 indicate a positive relationship between DM and increased risk of CRC with significant heterogeneity (I (2) = 92% and P-value < 0.05).Results from this systematic review and meta-analysis report that diabetic people have an increased risk of CRC as compared to non-diabetics." @default.
- W785937037 created "2016-06-24" @default.
- W785937037 creator A5009601625 @default.
- W785937037 date "2015-05-21" @default.
- W785937037 modified "2023-09-25" @default.
- W785937037 title "Association of type 2 diabetes mellitus and the risk of colorectal cancer: A meta-analysis and systematic review" @default.
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- W785937037 doi "https://doi.org/10.3748/wjg.v21.i19.6026" @default.
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