Matches in SemOpenAlex for { <https://semopenalex.org/work/W78605635> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W78605635 endingPage "24" @default.
- W78605635 startingPage "213" @default.
- W78605635 abstract "Cavinton was introduced into the clinical practice some twenty years ago in Hungary for the treatment of cerebrovascular disorders and related symptoms. Since then, its active ingredient, vinpocetine, beside its therapeutical utilization, has become a reference compound in the pharmacological research of cognitive deficits caused by hypoxia and ischaemia as well as in the cellular and biochemical investigations related to cyclic nucleotides. In this review a survey is given on the experimental data obtained with vinpocetine and an attempt is made to outline the drug's mechanism of action. Early experiments with vinpocetine indicated five main pharmacological and biochemical actions: (1) selective enhancement of the brain circulation and oxygen utilization without significant alteration in parameters of systemic circulation, (2) increased tolerance of the brain toward hypoxia and ischemia, (3) anticonvulsant activity, (4) inhibitory effect on phosphodiesterase (PDE) enzyme and (5) improvement of rheological properties of the blood and inhibition of aggregation of thrombocytes. Later studies in various laboratories confirmed the above effects and clearly demonstrated that vinpocetine offers significant and direct neuroprotection both under in vitro and in vivo conditions. Evidence has been obtained that neuroprotective action vinpocetine is related to the inhibition of operation of voltage dependent neuronal Na(+)-channels, indirect inhibition of some molecular cascades initiated by the rise of intracellular Ca(2+)-levels and, to a lesser extent, inhibition of adenosine reuptake. Vinpocetine has been shown to be selective inhibitor of Ca(2+)-calmodulin dependent cGMP-PDE. It is assumed that this inhibition enhances intracellular a GMP levels in the vascular smooth muscle leading to reduced resistance of cerebral vessels and increase of cerebral flow. This effect might also beneficially contribute to the neuroprotective action." @default.
- W78605635 created "2016-06-24" @default.
- W78605635 creator A5018033395 @default.
- W78605635 creator A5020070447 @default.
- W78605635 date "1996-09-01" @default.
- W78605635 modified "2023-09-23" @default.
- W78605635 title "[Mechanism of action of vinpocetine]." @default.
- W78605635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9082841" @default.
- W78605635 hasPublicationYear "1996" @default.
- W78605635 type Work @default.
- W78605635 sameAs 78605635 @default.
- W78605635 citedByCount "13" @default.
- W78605635 countsByYear W786056352012 @default.
- W78605635 countsByYear W786056352013 @default.
- W78605635 countsByYear W786056352014 @default.
- W78605635 countsByYear W786056352015 @default.
- W78605635 countsByYear W786056352020 @default.
- W78605635 countsByYear W786056352022 @default.
- W78605635 crossrefType "journal-article" @default.
- W78605635 hasAuthorship W78605635A5018033395 @default.
- W78605635 hasAuthorship W78605635A5020070447 @default.
- W78605635 hasConcept C126322002 @default.
- W78605635 hasConcept C178790620 @default.
- W78605635 hasConcept C181199279 @default.
- W78605635 hasConcept C185592680 @default.
- W78605635 hasConcept C202751555 @default.
- W78605635 hasConcept C25498285 @default.
- W78605635 hasConcept C2776120743 @default.
- W78605635 hasConcept C2778788455 @default.
- W78605635 hasConcept C540031477 @default.
- W78605635 hasConcept C541997718 @default.
- W78605635 hasConcept C55493867 @default.
- W78605635 hasConcept C62826618 @default.
- W78605635 hasConcept C71924100 @default.
- W78605635 hasConcept C7836513 @default.
- W78605635 hasConcept C79879829 @default.
- W78605635 hasConcept C98274493 @default.
- W78605635 hasConceptScore W78605635C126322002 @default.
- W78605635 hasConceptScore W78605635C178790620 @default.
- W78605635 hasConceptScore W78605635C181199279 @default.
- W78605635 hasConceptScore W78605635C185592680 @default.
- W78605635 hasConceptScore W78605635C202751555 @default.
- W78605635 hasConceptScore W78605635C25498285 @default.
- W78605635 hasConceptScore W78605635C2776120743 @default.
- W78605635 hasConceptScore W78605635C2778788455 @default.
- W78605635 hasConceptScore W78605635C540031477 @default.
- W78605635 hasConceptScore W78605635C541997718 @default.
- W78605635 hasConceptScore W78605635C55493867 @default.
- W78605635 hasConceptScore W78605635C62826618 @default.
- W78605635 hasConceptScore W78605635C71924100 @default.
- W78605635 hasConceptScore W78605635C7836513 @default.
- W78605635 hasConceptScore W78605635C79879829 @default.
- W78605635 hasConceptScore W78605635C98274493 @default.
- W78605635 hasIssue "5" @default.
- W78605635 hasLocation W786056351 @default.
- W78605635 hasOpenAccess W78605635 @default.
- W78605635 hasPrimaryLocation W786056351 @default.
- W78605635 hasRelatedWork W174689142 @default.
- W78605635 hasRelatedWork W1976614131 @default.
- W78605635 hasRelatedWork W1991748266 @default.
- W78605635 hasRelatedWork W2094024817 @default.
- W78605635 hasRelatedWork W2115847650 @default.
- W78605635 hasRelatedWork W2322509087 @default.
- W78605635 hasRelatedWork W2752917280 @default.
- W78605635 hasRelatedWork W298539273 @default.
- W78605635 hasRelatedWork W3207171431 @default.
- W78605635 hasRelatedWork W78605635 @default.
- W78605635 hasVolume "66" @default.
- W78605635 isParatext "false" @default.
- W78605635 isRetracted "false" @default.
- W78605635 magId "78605635" @default.
- W78605635 workType "article" @default.