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- W786153897 abstract "Objective:According to observe the expression of TGF-β,Smad2 and Smad7 in glomerulosclerosis model, investigate the significance of TGF-β/Smad Signaling Pathway in the development of glomerulosclerosis.Methods:36 rats were randomly divided into control group and model group.Adriamycin nephropathy was induced in rats in the model groups by intravenous injection of adriamycin.The levels of 24 h urine protein(Upr),blood album(Alb)and blood urea nitrogen(BUN)of rats in each group were examined.The expression levels of TGF-β,Smad2 and Smad7 in renal tissue were detected by immunohistochemical method and fluorescent quantitation PCR.Results:TGF-β,Smad2 and Smad7 express fewly in mesangial cell,tubules epithelium and interstitial cell. The levels of TGFβ1,Smad2 protein and mRNA in renal tissue were increased in model group in the fourth,the sixth and the eighth week as compared with those in the control group.While the levels of Smad7 protein and mRNA were decreased gradually compared with control group.Conclusion:TGF-β/Smad Signaling Pathway Chinese participates in the development of glomerulosclerosis.Smad7 maybe the inhibitor of TGF-β/Smad Signaling Pathway,which will be a new therapy to glomerulosclerosis." @default.
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- W786153897 date "2009-01-01" @default.
- W786153897 modified "2023-09-28" @default.
- W786153897 title "Expression of TGF-β/Smad Signaling Pathway and Its Significance in Glomerulosclerosis Model" @default.
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