Matches in SemOpenAlex for { <https://semopenalex.org/work/W787579729> ?p ?o ?g. }
- W787579729 endingPage "e0132722" @default.
- W787579729 startingPage "e0132722" @default.
- W787579729 abstract "Aripiprazole is a wide-used antipsychotic drug with therapeutic effects on both positive and negative symptoms of schizophrenia, and reduced side-effects. Although aripiprazole was developed as a dopamine D2 receptor (D2R) partial agonist, all other D2R partial agonists that aimed to mimic aripiprazole failed to exert therapeutic effects in clinic. The present in vivo study aimed to investigate the effects of aripiprazole on the D2R downstream cAMP-PKA and Akt-GSK3β signalling pathways in comparison with a D2R antagonist--haloperidol and a D2R partial agonist--bifeprunox. Rats were injected once with aripiprazole (0.75 mg/kg, i.p.), bifeprunox (0.8 mg/kg, i.p.), haloperidol (0.1 mg/kg, i.p.) or vehicle. Five brain regions--the prefrontal cortex (PFC), nucleus accumbens (NAc), caudate putamen (CPu), ventral tegmental area (VTA) and substantia nigra (SN) were collected. The protein levels of PKA, Akt and GSK3β were measured by Western Blotting; the cAMP levels were examined by ELISA tests. The results showed that aripiprazole presented similar acute effects on PKA expression to haloperidol, but not bifeprunox, in the CPU and VTA. Additionally, aripiprazole was able to increase the phosphorylation of GSK3β in the PFC, NAc, CPu and SN, respectively, which cannot be achieved by bifeprunox and haloperidol. These results suggested that acute treatment of aripiprazole had differential effects on the cAMP-PKA and Akt-GSK3β signalling pathways from haloperidol and bifeprunox in these brain areas. This study further indicated that, by comparison with bifeprunox, the unique pharmacological profile of aripiprazole may be attributed to the relatively lower intrinsic activity at D2R." @default.
- W787579729 created "2016-06-24" @default.
- W787579729 creator A5002681207 @default.
- W787579729 creator A5040465739 @default.
- W787579729 creator A5040616081 @default.
- W787579729 creator A5055567713 @default.
- W787579729 creator A5058107287 @default.
- W787579729 date "2015-07-10" @default.
- W787579729 modified "2023-09-24" @default.
- W787579729 title "Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3β Signalling Pathways in Rats" @default.
- W787579729 cites W1499533611 @default.
- W787579729 cites W1546116904 @default.
- W787579729 cites W1550813715 @default.
- W787579729 cites W1576381397 @default.
- W787579729 cites W1830139488 @default.
- W787579729 cites W1834529319 @default.
- W787579729 cites W1929648989 @default.
- W787579729 cites W1944617386 @default.
- W787579729 cites W1964684914 @default.
- W787579729 cites W1966715692 @default.
- W787579729 cites W1967179993 @default.
- W787579729 cites W1969487195 @default.
- W787579729 cites W1970155580 @default.
- W787579729 cites W1971179661 @default.
- W787579729 cites W1971676848 @default.
- W787579729 cites W1976048970 @default.
- W787579729 cites W1978559289 @default.
- W787579729 cites W1979777611 @default.
- W787579729 cites W1980589735 @default.
- W787579729 cites W1980980884 @default.
- W787579729 cites W1985819300 @default.
- W787579729 cites W1986185847 @default.
- W787579729 cites W1986827208 @default.
- W787579729 cites W1990090741 @default.
- W787579729 cites W1995540460 @default.
- W787579729 cites W1999667319 @default.
- W787579729 cites W2000480527 @default.
- W787579729 cites W2014820398 @default.
- W787579729 cites W2014862375 @default.
- W787579729 cites W2016781419 @default.
- W787579729 cites W2016946796 @default.
- W787579729 cites W2018150079 @default.
- W787579729 cites W2029701200 @default.
- W787579729 cites W2032819792 @default.
- W787579729 cites W2034843065 @default.
- W787579729 cites W2036424845 @default.
- W787579729 cites W2037574869 @default.
- W787579729 cites W2044297736 @default.
- W787579729 cites W2046591682 @default.
- W787579729 cites W2046929321 @default.
- W787579729 cites W2047356082 @default.
- W787579729 cites W2047847377 @default.
- W787579729 cites W2051792029 @default.
- W787579729 cites W2053070706 @default.
- W787579729 cites W2053959292 @default.
- W787579729 cites W2059000943 @default.
- W787579729 cites W2060576062 @default.
- W787579729 cites W2064729301 @default.
- W787579729 cites W2065382981 @default.
- W787579729 cites W2066520436 @default.
- W787579729 cites W2067592930 @default.
- W787579729 cites W2070357412 @default.
- W787579729 cites W2074283636 @default.
- W787579729 cites W2075089390 @default.
- W787579729 cites W2082441632 @default.
- W787579729 cites W2082956345 @default.
- W787579729 cites W2086717751 @default.
- W787579729 cites W2091991835 @default.
- W787579729 cites W2092314400 @default.
- W787579729 cites W2107266956 @default.
- W787579729 cites W2117456134 @default.
- W787579729 cites W2121473111 @default.
- W787579729 cites W2126094071 @default.
- W787579729 cites W2126132542 @default.
- W787579729 cites W2138681004 @default.
- W787579729 cites W2140864873 @default.
- W787579729 cites W2141425802 @default.
- W787579729 cites W2141524439 @default.
- W787579729 cites W2144939635 @default.
- W787579729 cites W2149977756 @default.
- W787579729 cites W2153763527 @default.
- W787579729 cites W2155500949 @default.
- W787579729 cites W2157457391 @default.
- W787579729 cites W2158321076 @default.
- W787579729 cites W2159996636 @default.
- W787579729 cites W2166977877 @default.
- W787579729 cites W2883138316 @default.
- W787579729 cites W4246353915 @default.
- W787579729 cites W69345561 @default.
- W787579729 cites W88795552 @default.
- W787579729 doi "https://doi.org/10.1371/journal.pone.0132722" @default.
- W787579729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4498891" @default.
- W787579729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26162083" @default.
- W787579729 hasPublicationYear "2015" @default.
- W787579729 type Work @default.
- W787579729 sameAs 787579729 @default.
- W787579729 citedByCount "25" @default.
- W787579729 countsByYear W7875797292016 @default.