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- W78759314 abstract "Background: Dengue disease encompasses a wide spectrum of clinical presentations. While the severity of dengue disease can vary from patient to patient, it is, however, still unclear as to what factors determine dengue disease severity. Objective: To analyze the potential risk factors such as: sex, age, nutritional status, dengue serotypes, D-dimer positivity, and serologic responses, and study their correlation with the severity of dengue virus infection. Methods: Dengue patients at King Chulalongkorn Memorial Hospital were enrolled for the study. Dengue serotype was determined by PCR and primary or secondary infection was determined based on serological criteria. D-dimer levels were also tested using a rapid semiquantitation system. Clinical data such as age, body weight, sex, and nutritional status were also collected. Results: Forty-six patients were confirmed for dengue fever (DF), and 52 patients were confirmed for Dengue hemorrhagic fever (DHF). 77.5% of patients had secondary dengue infection, 11.3% had primary infection, and 11.2% were of inconclusive status. Gender and age of patients did not correlate with dengue disease severity (p > 0.05). It was inconclusive as to whether nutritional status was a risk factor. Positivity of the D-dimer test was statistically significant for DHF (p=0.001). Early increasing D-dimer in the febrile stage could predict severity of dengue infection during the initial stage of the disease (positive predictive value=68.4 %). Conclusion: D-dimer is significantly correlated with dengue severity and it may be one of the prognostic factors for dengue infection in children." @default.
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- W78759314 date "2010-01-26" @default.
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- W78759314 title "Risk factors influencing severity in pediatric dengue infection" @default.
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- W78759314 doi "https://doi.org/10.5372/abm.v2i5.212" @default.
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