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- W787602018 abstract "Publisher Summary In the experiment described in the chapter, the myelin breakdown with relative sparing of axons (segmental demyelination), which occurs in experimental diphtheritic neuritis, was studied electron microscopically for clarifying the mechanism of myelin destruction and formation in Schwann cells. Focal alterations in the lamellar pattern of myelin were present at the onset of clinical symptoms. Then, the myelin sheath became discontinuous. Intracytoplasmic membranes separated the myelin fragments from the axon. Later, the axon and myelin remnants occupied opposite margins of the Schwann cell. Finally, the myelin breakdown products appeared in isolated islands of Schwann cell cytoplasm adjacent to macrophages. During remyelination of the surviving axon by the Schwann cell, the arrangement of mesaxons and cytoplasmic organelles was frequently complex. The variations in contour of newly formed myelin were similar to those observed in normal nerve fibers during myelinogenesis." @default.
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- W787602018 date "1964-01-01" @default.
- W787602018 modified "2023-09-26" @default.
- W787602018 title "Some Ultrastructural Features of Segmental Demyelination and Myelin Regeneration in Peripheral Nerve" @default.
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- W787602018 doi "https://doi.org/10.1016/s0079-6123(08)60143-0" @default.
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