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• W788005057 abstract "Abstract MRI, magnetic resonance imaging, is used for disease detection such as assessing blood flow, detecting tumours and diagnosing many forms of cancer. Contrast agents are chemical substances that increase the MRI sensitivity. One class of contrast agents are the so called nanoparticulate contrast agents. Since tumour-associated formation of new blood vessels often results in highly permeable vessels, appropriately sized nanoparticles can selectively leak from the blood flow into the tumour interstitium and accumulate in tumours. This creates an increased difference in contrast between normal and abnormal tissue in an image. Spago Imaging AB is developing a novel and tumour specific nanoparticle based contrast agent. In solving the clinical evaluation of the nanoparticle it is important to know how the nanoparticle interacts with specific cells and tissues types. In this thesis work, an in vitro based assay was developed so that one aspect of the nanoparticle cell interactions can be studied; cellular uptake. The assay was developed using three reference particles, PEGylated gold nanoparticles and Superparamagnetic iron oxide nanoparticles (SPIO) which were in this study successfully functionalized with PEG1000 and APTMS. All three are known from literature to be internalized in certain cell lines [1-3]. HepG2 hepatocytes cells and human breast carcinoma cells MDA-MB-231 cells were used as models. By investigating the effect of cell density and amount, exposure time, nanoparticle concentration and particle surface characteristics, a functional assay could be set up. ICP-AES analysis and T1 and T2 relaxivity measurments showed that the internalization of nanoparticles occurred in a concentration dependant manner. The assay was used to test cellular uptake of a precursor of Spago Imaging AB Ion-X-gel, itself a staring material for the final contrast agent product. The findings indicated that the Ion-X-Gel precursor was internalized in a concentration dependent manner. The study also demonstrated that silane-coated SPIO nanoparticles possessed a higher in vitro labeling efficiency in HepG2 cells compared to PEG coated SPIO nanoparticles. The results will give a better understanding of how the nanoparticles behave in a biological system and can in the long run help the developmental process to produce a product with the potential to provide more accurate diagnosis, earlier detection of tumours, a decrease in the number of false positives and above all, it could lead to less suffering for patients." @default.
• W788005057 created "2016-06-24" @default.
• W788005057 creator A5034059060 @default.
• W788005057 date "2013-01-01" @default.
• W788005057 modified "2023-09-27" @default.
• W788005057 title "Development of an in vitro assay for analysis of cellular uptake of nanoparticles" @default.
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